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Our Lab

Our research interests are focused on the understanding of the molecular mechanisms which lead to neurodegeneration in diseases such as Parkinson’s, Huntington’s, or Alzheimer’s disease. These diseases are intimately associated with protein misfolding and aggregation in specific regions of the brain.
Because the molecular pathways involved in protein homeostasis are highly conserved, we employ a wide variety of model organisms, from the simple but powerful budding yeast to mammalian cell culture and mice, to study the origin of the problems.
Our ultimate goals are to develop novel therapeutic approaches for these and other related disorders. We are working closely together with clinicians in order to accelerate drug discovery efforts, translating basic research into clinical applications that will improve the lives of patients.

Research Areas

  • Protein misfolding, oligomerization and aggregation

  • Yeast models for Parkinson’s and Huntington’s disease

  • Modulators of protein aggregation and toxicity

  • Microscopy-based methods for investigating the molecular nature of the toxic proteinaceous species in Parkinson’s disease

  • In vivo imaging using multi-photon microscopy

  • Development of novel therapeutic approaches for neurodegenerative disease

Head of the Department
Head of the DepartmentProf. Dr. Tiago Outeiro
ORCIDResearchgatePubMed

Highlights

A biological classification of Parkinson’s disease: the SynNeurGe research diagnostic criteria

January 29th, 2024|Categories: News & Events|

A biological classification of Parkinson's disease: the SynNeurGe research diagnostic criteria With the hope that disease-modifying treatments could target the molecular basis of Parkinson's disease, even before the [...]

February 4th, 2020|Categories: News & Events|

Neurodegenerative disorders, including Alzheimer’s disease (AD) and Parkinson ’s disease (PD), affect more than eleven million European citizens, and result in major suffering for patients and [...]

Selected Publications

April 29th, 2024|Categories: Selected Publications|

Exact mechanisms of heat shock–induced lifespan extension, although documented across species, are still not well understood. Here, we show that fully functional peroxisomes, specifically peroxisomal catalase, are needed [...]

A biological classification of Parkinson’s disease: the SynNeurGe research diagnostic criteria.

April 29th, 2024|Categories: Selected Publications|

With the hope that disease-modifying treatments could target the molecular basis of Parkinson's disease, even before the onset of symptoms, we propose a biologically based classification. Our classification [...]

Chemical synthesis of site-selective advanced glycation end products in α-synuclein and its fragments.

April 29th, 2024|Categories: Selected Publications|

Advanced glycation end products (AGEs) arise from the Maillard reaction between dicarbonyls and proteins, nucleic acids, or specific lipids. Notably, AGEs are linked to aging and implicated in [...]

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