Systematic Comparison of the Effects of Alpha-synuclein Mutations on Its Oligomerization and Aggregation
Aggregation of alpha-synuclein (ASYN) in Lewy bodies and Lewy neurites is the typical pathological hallmark of Parkinson’s […]
The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease
Sirtuin genes have been associated with aging and are known to affect multiple cellular pathways. Sirtuin 2 was previously […]
Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity
Synucleinopathies are a group of progressive disorders characterized by the abnormal aggregation and accumulation of α-synuclein (aSyn), an abundant […]
Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies
α-Synuclein misfolding and aggregation is a hallmark in Parkinson’s disease and in several other neurodegenerative diseases known as synucleinopathies. […]
α-synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B
Synucleinopathies, such as Parkinson’s disease and dementia with Lewy bodies, are neurodegenerative disorders that are characterized by the accumulation […]
Nuclear localization and phosphorylation modulate pathological effects of Alpha-Synuclein
Alpha-synuclein (aSyn) is a central player in Parkinson’s disease (PD) but the precise molecular mechanisms underlying its pathogenicity remain […]