Papers

PrP meets alpha-synuclein: Molecular mechanisms and implications for disease.
Vieira TCRG, Barros CA, Domingues R, Outeiro TF.
J Neurochem. 2023 Oct 19. doi: 10.1111/jnc.15992. Online ahead of print.
PMID: 37855859 Review.
PubMed

Glucocerebrosidase mutations disrupt the lysosome and now the mitochondria.
Klein AD, Outeiro TF.
Nat Commun. 2023 Oct 11;14(1):6383. doi: 10.1038/s41467-023-42107-7.
PMID: 37821433 Free PMC article.
PubMed

Changes in α-Synuclein Posttranslational Modifications in an AAV-Based Mouse Model of Parkinson’s Disease.
Brembati V, Faustini G, Longhena F, Outeiro TF, Bellucci A.
Int J Mol Sci. 2023 Aug 30;24(17):13435. doi: 10.3390/ijms241713435.
PMID: 37686236 Free PMC article.
PubMed

Increased alpha-synuclein and neuroinflammation in the substantia nigra triggered by systemic inflammation are reversed by targeted inhibition of the receptor for advanced glycation end products (RAGE).
Peixoto DO, Bittencourt RR, Gasparotto J, Kessler FGC, Brum PO, Somensi N, Girardi CS, Dos Santos da Silva L, Outeiro TF, Moreira JCF, Gelain DP.
J Neurochem. 2023 Sep 3. doi: 10.1111/jnc.15956. Online ahead of print.
PMID: 37661637
PubMed

Beyond Motor Deficits: Environmental Enrichment Mitigates Huntington’s Disease Effects in YAC128 Mice.
Plácido E, Gomes Welter P, Wink A, Karasiak GD, Outeiro TF, Dafre AL, Gil-Mohapel J, Brocardo PS.
Int J Mol Sci. 2023 Aug 9;24(16):12607. doi: 10.3390/ijms241612607.
PubMed

The alpha-synuclein oligomers activate nuclear factor of activated T-cell (NFAT) modulating synaptic homeostasis and apoptosis.
Sant’Anna R, Robbs BK, de Freitas JA, Dos Santos PP, König A, Outeiro TF, Foguel D.
Mol Med. 2023 Aug 18;29(1):111. doi: 10.1186/s10020-023-00704-8.
PMID: 37596531 Free PMC article.
PubMed

Glycation modulates superoxide dismutase 1 aggregation and toxicity in models of sporadic amyotrophic lateral sclerosis.
Monteiro Neto JR, Ribeiro GD, Magalhães RSS, Follmer C, Outeiro TF, Eleutherio ECA.
Biochim Biophys Acta Mol Basis Dis. 2023 Dec;1869(8):166835. doi: 10.1016/j.bbadis.2023.166835. Epub 2023 Aug 7.
PMID: 37558009
PubMed

Aggregation and beyond: alpha-synuclein-based biomarkers in synucleinopathies.
Chopra A, Outeiro TF.
Brain. 2024 Jan 4;147(1):81-90. doi: 10.1093/brain/awad260.
PMID: 37526295
PubMed

Proteomic analysis of the human hippocampus identifies neuronal pentraxin 1 (NPTX1) as synapto-axonal target in late-stage Parkinson’s disease.
Warth Perez Arias CC, Silbern I, Caldi Gomes L, Wartmann H, Dambeck V, Fanz J, Neuenroth L, Bähr M, Outeiro TF, Bonn S, Stadelmann-Nessler C, Rizzoli SO, Lenz C, Urlaub H, Lingor P.
J Neurochem. 2023 Sep;166(5):862-874. doi: 10.1111/jnc.15924. Epub 2023 Jul 28.
PMID: 37515330
PubMed

Extracellular Vesicles for the Diagnosis of Parkinson’s Disease: Systematic Review and Meta-Analysis.
Xylaki M, Chopra A, Weber S, Bartl M, Outeiro TF, Mollenhauer B.
Mov Disord. 2023 Sep;38(9):1585-1597. doi: 10.1002/mds.29497. Epub 2023 Jul 14.
PMID: 37449706 Review.
PubMed

More than meets the eye in Parkinson’s disease and other synucleinopathies: from proteinopathy to lipidopathy.
Flores-Leon M, Outeiro TF.
Acta Neuropathol. 2023 Sep;146(3):369-385. doi: 10.1007/s00401-023-02601-0. Epub 2023 Jul 8.
PMID: 37421475 Free PMC article. Review.
PubMed

AI and protein structure and function in neurological disease: relevance to disease management.
Outeiro TF, Vieira TCRG.
Nat Rev Neurol. 2023 Aug;19(8):453-454. doi: 10.1038/s41582-023-00840-z.
PMID: 37394622 No abstract available.
PubMed

Is it all the RAGE? Defining the role of the receptor for advanced glycation end products in Parkinson’s disease.
Gasparotto J, Somensi N, Girardi CS, Bittencourt RR, de Oliveira LM, Hoefel LP, Scheibel IM, Peixoto DO, Moreira JCF, Outeiro TF, Gelain DP.
J Neurochem. 2023 Jun 28. doi: 10.1111/jnc.15890. Online ahead of print.
PMID: 37381043 Review.
PubMed

Targeting Biomolecular Condensation and Protein Aggregation against Cancer.
Silva JL, Foguel D, Ferreira VF, Vieira TCRG, Marques MA, Ferretti GDS, Outeiro TF, Cordeiro Y, de Oliveira GAP.
Chem Rev. 2023 Jul 26;123(14):9094-9138. doi: 10.1021/acs.chemrev.3c00131. Epub 2023 Jun 28.
PMID: 37379327 Review.
PubMed

Editorial: Personalized care in neurological diseases.
Fernandes JB, Godinho C, Outeiro TF, Baixinho CL.
Front Hum Neurosci. 2023 May 30;17:1216902. doi: 10.3389/fnhum.2023.1216902. eCollection 2023.
PMID: 37323934 Free PMC article. No abstract available.
PubMed

RAGE Against the Glycation Machine in Synucleinopathies: Time to Explore New Questions.
Gelain DP, Bittencourt RR, Bastos Mendes LF, Moreira JCF, Outeiro TF.
J Parkinsons Dis. 2023;13(5):717-728. doi: 10.3233/JPD-230070.
PMID: 37270812 Free PMC article. Review.
PubMed

People with Early Onset Parkinson’s Disease: Empowered to Improve Care.
Domingos J, Teixeira Bastos MDC, Couto R, Cameira AR, Cardoso AL, Reffóios A, Magalhães S, Massano J, Outeiro TF.
J Parkinsons Dis. 2023;13(4):633-636. doi: 10.3233/JPD-230039.
PMID: 37182901 Free PMC article.
PubMed

Defining the Riddle in Order to Solve It: There Is More Than One “Parkinson’s Disease”.
Outeiro TF, Alcalay RN, Antonini A, Attems J, Bonifati V, Cardoso F, Chesselet MF, Hardy J, Madeo G, McKeith I, Mollenhauer B, Moore DJ, Rascol O, Schlossmacher MG, Soreq H, Stefanis L, Ferreira JJ.
Mov Disord. 2023 Jul;38(7):1127-1142. doi: 10.1002/mds.29419. Epub 2023 May 8.
PMID: 37156737 Review.
PubMed

Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage.
Rosado-Ramos R, Poças GM, Marques D, Foito A, M Sevillano D, Lopes-da-Silva M, Gonçalves LG, Menezes R, Ottens M, Stewart D, Ibáñez de Opakua A, Zweckstetter M, Seabra MC, Mendes CS, Outeiro TF, Domingos PM, Santos CN.
Nat Commun. 2023 Apr 6;14(1):1918. doi: 10.1038/s41467-023-37561-2.
PMID: 37024503 Free PMC article.
PubMed

Chemical Synthesis of Alpha-Synuclein Proteins via Solid-Phase Peptide Synthesis and Native Chemical Ligation.
Gatzemeier LM, Meyer F, Diederichsen U, Outeiro TF.
Chemistry. 2023 Jun 13;29(33):e202300649. doi: 10.1002/chem.202300649. Epub 2023 Apr 27.
PMID: 36971510
PubMed

Intermittent Lead Exposure Induces Behavioral and Cardiovascular Alterations Associated with Neuroinflammation.
Shvachiy L, Amaro-Leal Â, Outeiro TF, Rocha I, Geraldes V.
Cells. 2023 Mar 6;12(5):818. doi: 10.3390/cells12050818.
PMID: 36899953 Free PMC article.
PubMed

Stem Cell Therapies in Movement Disorders: Lessons from Clinical Trials.
Marsili L, Sharma J, Outeiro TF, Colosimo C.
Biomedicines. 2023 Feb 9;11(2):505. doi: 10.3390/biomedicines11020505.
PMID: 36831041
PubMed

Glycosylation spectral signatures for glioma grade discrimination using Raman spectroscopy.
Quesnel A, Coles N, Angione C, Dey P, Polvikoski TM, Outeiro TF, Islam M, Khundakar AA, Filippou PS.
BMC Cancer. 2023 Feb 21;23(1):174. doi: 10.1186/s12885-023-10588-w.
PubMed

Stem Cell Therapies in Movement Disorders: Lessons from Clinical Trials.
Marsili L, Sharma J, Outeiro TF, Colosimo C.
Biomedicines. 2023 Feb 9;11(2):505. doi: 10.3390/biomedicines11020505.
PubMed

miR-101a-3p Impairs Synaptic Plasticity and Contributes to Synucleinopathy.
Xylaki M, Paiva I, Al-Azzani M, Gerhardt E, Jain G, Islam MR, Vasili E, Wassouf Z, Schulze-Hentrich JM, Fischer A, Outeiro TF.J Parkinsons Dis. 2023 Feb 1. doi: 10.3233/JPD-225055. Online ahead of print.
PubMed

The immune system in Parkinson’s disease: From biology to diagnosis and therapeutic targets.
Outeiro TF, El-Agnaf OM.
Neurobiol Dis. 2023 Feb;177:105995. doi: 10.1016/j.nbd.2023.105995. Epub 2023 Jan 7.
PubMed

Type 2 Diabetes and Parkinson’s Disease: A Focused Review of Current Concepts.
Cullinane PW, de Pablo Fernandez E, König A, Outeiro TF, Jaunmuktane Z, Warner TT.
Mov Disord. 2023 Feb;38(2):162-177. doi: 10.1002/mds.29298. Epub 2022 Dec 26.
PubMed

Non-SUMOylated alternative spliced isoforms of alpha-synuclein are more aggregation-prone and toxic.
Hassanzadeh K, Morrone C, Akhtari K, Gerhardt E, Zaccagnini L, Outeiro TF, Feligioni M.
Mech Ageing Dev. 2023 Jan;209:111759. doi: 10.1016/j.mad.2022.111759. Epub 2022 Dec 2.
PubMed

Mutation of Tyrosine Sites in the Human Alpha-Synuclein Gene Induces Neurotoxicity in Transgenic Mice with Soluble Alpha-Synuclein Oligomer Formation.
Lassen LB, Thomsen MS, Basso E, Füchtbauer EM, Füchtbauer A, Outeiro TF, Jensen PH, Moos T.
Cells. 2022 Nov 18;11(22):3673. doi: 10.3390/cells11223673.
PubMed

Kynurenine 3-Monooxygenase Interacts with Huntingtin at the Outer Mitochondrial Membrane.
Swaih AM, Breda C, Sathyasaikumar KV, Allcock N, Collier MEW, Mason RP, Feasby A, Herrera F, Outeiro TF, Schwarcz R, Repici M, Giorgini F.
Biomedicines. 2022 Sep 15;10(9):2294. doi: 10.3390/biomedicines10092294.
PubMed

Ectosomes and exosomes modulate neuronal spontaneous activity.
Brás IC, Khani MH, Riedel D, Parfentev I, Gerhardt E, van Riesen C, Urlaub H, Gollisch T, Outeiro TF.
J Proteomics. 2022 Sep 8:104721. doi: 10.1016/j.jprot.2022.104721. Online ahead of print.
PubMed

From Molecular to Functional Effects of Different Environmental Lead Exposure Paradigms.
Shvachiy L, Amaro-Leal Â, Outeiro TF, Rocha I, Geraldes V.
Biology (Basel). 2022 Aug 3;11(8):1164. doi: 10.3390/biology11081164.
PubMed

JM-20, a Benzodiazepine-Dihydropyridine Hybrid Molecule, Inhibits the Formation of Alpha-Synuclein-Aggregated Species.
Santos CC, Cardim-Pires TR, Shvachiy L, Fonseca-Fonseca LA, Muñoz P, Almeida ÁMAN, Costa ACS, Teles-Souza J, Ochoa-Rodríguez E, de Fátima Dias Costa M, Palhano FL, Segura-Aguilar J, Barbosa DB, do Bomfim MR, Dos Santos Junior MC, Leite FHA, da Rocha Pita SS, Costa SL, Núñez-Figueredo Y, Outeiro TF, Foguel D, Silva VDA.
Neurotox Res. 2022 Aug 23. doi: 10.1007/s12640-022-00559-7. Online ahead of print.
PubMed

Hexokinase 2: The preferential target of trehalose-6-phosphate over hexokinase 1.
Magalhães RSS, Boechat FC, Brasil AA, Neto JRM, Ribeiro GD, Paranhos LH, Neves de Souza N, Vieira T, Outeiro TF, Neves BC, Eleutherio ECA.
J Cell Biochem. 2022 Aug 9. doi: 10.1002/jcb.30317. Online ahead of print.
PubMed

Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies.
Koss DJ, Erskine D, Porter A, Palmoski P, Menon H, Todd OGJ, Leite M, Attems J, Outeiro TF.
Acta Neuropathol Commun. 2022 Jul 6;10(1):98. doi: 10.1186/s40478-022-01403-x.
PubMed

A water-soluble manganese(II) octanediaoate/phenanthroline complex acts as an antioxidant and attenuates alpha-synuclein toxicity.
Queiroz DD, Ribeiro TP, Gonçalves JM, Mattos LMM, Gerhardt E, Freitas J, Palhano FL, Frases S, Pinheiro AS, McCann M, Knox A, Devereux M, Outeiro TF, Pereira MD.
Biochim Biophys Acta Mol Basis Dis. 2022 Oct 1;1868(10):166475. doi: 10.1016/j.bbadis.2022.166475. Epub 2022 Jun 28.
PubMed

Aromaticity at position 39 in α-synuclein: A modulator of amyloid fibril assembly and membrane-bound conformations.
Buratti FA, Boeffinger N, Garro HA, Flores JS, Hita FJ, Gonçalves PDC, Copello FDR, Lizarraga L, Rossetti G, Carloni P, Zweckstetter M, Outeiro TF, Eimer S, Griesinger C, Fernández CO.
Protein Sci. 2022 Jul;31(7):e4360. doi: 10.1002/pro.4360.
PubMed

Editorial for the Special Issue “Adaptation, Aging, and Cell Death in Yeast Stress Response: Models, Mechanisms and Applications”.
Guaragnella N, Krisko A, Outeiro TF.
Microorganisms. 2022 May 30;10(6):1126. doi: 10.3390/microorganisms10061126.
PubMed

Therapeutic Targeting of Rab GTPases: Relevance for Alzheimer’s Disease.
Jordan KL, Koss DJ, Outeiro TF, Giorgini F.
Biomedicines. 2022 May 16;10(5):1141. doi: 10.3390/biomedicines10051141.
PubMed

Alpha-synuclein overexpression induces epigenomic dysregulation of glutamate signaling and locomotor pathways.
Schaffner SL, Wassouf Z, Lazaro DF, Xylaki M, Gladish N, Lin DTS, MacIsaac J, Ramadori K, Hentrich T, Schulze-Hentrich JM, Outeiro TF, Kobor MS.
Hum Mol Genet. 2022 May 14:ddac104. doi: 10.1093/hmg/ddac104. Online ahead of print.
PubMed

Glycation modulates glutamatergic signaling and exacerbates Parkinson’s disease-like phenotypes.
Chegão A, Guarda M, Alexandre BM, Shvachiy L, Temido-Ferreira M, Marques-Morgado I, Fernandes Gomes B, Matthiesen R, Lopes LV, Florindo PR, Gomes RA, Gomes-Alves P, Coelho JE, Outeiro TF, Vicente Miranda H.
NPJ Parkinsons Dis. 2022 Apr 25;8(1):51. doi: 10.1038/s41531-022-00314-x.
PubMed

The future of Parkinson’s disease research: A new paradigm of human-specific investigation is necessary… and possible.
Cassotta M, Geerts H, Harbom L, Outeiro TF, Pediaditakis I, Reiner O, Schildknecht S, Schwamborn JC, Bailey J, Herrmann K, Hogberg HT.
ALTEX. 2022 Apr 8. doi: 10.14573/altex.2203161. Online ahead of print.
PubMed

The small aromatic compound SynuClean-D inhibits the aggregation and seeded polymerization of multiple α-synuclein strains.
Peña-Díaz S, Pujols J, Vasili E, Pinheiro F, Santos J, Manglano-Artuñedo Z, Outeiro TF, Ventura S.
J Biol Chem. 2022 May;298(5):101902. doi: 10.1016/j.jbc.2022.101902. Epub 2022 Apr 4.
PubMe

α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity.
Ghanem SS, Majbour NK, Vaikath NN, Ardah MT, Erskine D, Jensen NM, Fayyad M, Sudhakaran IP, Vasili E, Melachroinou K, Abdi IY, Poggiolini I, Santos P, Dorn A, Carloni P, Vekrellis K, Attems J, McKeith I, Outeiro TF, Jensen PH, El-Agnaf OMA.
Proc Natl Acad Sci U S A. 2022 Apr 12;119(15):e2109617119. doi: 10.1073/pnas.2109617119. Epub 2022 Mar 30.
PubMed

Extracellular alpha-synuclein: Sensors, receptors, and responses.
Domingues R, Sant’Anna R, da Fonseca ACC, Robbs BK, Foguel D, Outeiro TF.
Neurobiol Dis. 2022 Jun 15;168:105696. doi: 10.1016/j.nbd.2022.105696. Epub 2022 Mar 20.
PubMed

Glycation modulates alpha-synuclein fibrillization kinetics: A sweet spot for inhibition.
Farzadfard A, König A, Petersen SV, Nielsen J, Vasili E, Dominguez-Meijide A, Buell AK, Outeiro TF, Otzen DE.
J Biol Chem. 2022 May;298(5):101848. doi: 10.1016/j.jbc.2022.101848. Epub 2022 Mar 18.
PubMed

Production of Recombinant Alpha-Synuclein: Still No Standardized Protocol in Sight.
Al-Azzani M, König A, Outeiro TF.
Biomolecules. 2022 Feb 18;12(2):324. doi: 10.3390/biom12020324.
PubMed

Monitoring the interactions between alpha-synuclein and Tau in vitro and in vivo using bimolecular fluorescence complementation.
Torres-Garcia L, P Domingues JM, Brandi E, Haikal C, Mudannayake JM, Brás IC, Gerhardt E, Li W, Svanbergsson A, Outeiro TF, Gouras GK, Li JY.
Sci Rep. 2022 Feb 22;12(1):2987. doi: 10.1038/s41598-022-06846-9.
PubMed

Prion-like α-synuclein pathology in the brain of infants with Krabbe disease.
Hatton C, Ghanem SS, Koss DJ, Abdi IY, Gibbons E, Guerreiro R, Bras J; International DLB Genetics Consortium, Walker L, Gelpi E, Heywood W, Outeiro TF, Attems J, McFarland R, Forsyth R, El-Agnaf OM, Erskine D.
Brain. 2022 May 24;145(4):1257-1263. doi: 10.1093/brain/awac002.
PubMed

Endogenous Levels of Alpha-Synuclein Modulate Seeding and Aggregation in Cultured Cells.
Vasili E, Dominguez-Meijide A, Flores-León M, Al-Azzani M, Kanellidi A, Melki R, Stefanis L, Outeiro TF.
Mol Neurobiol. 2022 Feb;59(2):1273-1284. doi: 10.1007/s12035-021-02713-2. Epub 2022 Jan 4.
PubMed

JM-20 treatment prevents neuronal damage and memory impairment induced by aluminum chloride in rats.
Wong-Guerra M, Montano-Peguero Y, Ramírez-Sánchez J, Jiménez-Martin J, Fonseca-Fonseca LA, Hernández-Enseñat D, Nonose Y, Valdés O, Mondelo-Rodriguez A, Ortiz-Miranda Y, Bergado G, Carmenate T, Soto Del Valle RM, Pardo-Andreu G, Outeiro TF, Padrón-Yaquis AS, Martimbianco de Assis A, O Souza D, Nuñez-Figueredo Y.
Neurotoxicology. 2021 Dec;87:70-85. doi: 10.1016/j.neuro.2021.08.017. Epub 2021 Sep 2.
PubMed

Cellular Prion Protein Mediates α-Synuclein Uptake, Localization, and Toxicity In Vitro and In Vivo.
Thom T, Schmitz M, Fischer AL, Correia A, Correia S, Llorens F, Pique AV, Möbius W, Domingues R, Zafar S, Stoops E, Silva CJ, Fischer A, Outeiro TF, Zerr I.
Mov Disord. 2022 Jan;37(1):39-51. doi: 10.1002/mds.28774. Epub 2021 Aug 27.
PubMed 

Alpha-synuclein research: defining strategic moves in the battle against Parkinson’s disease.
Oliveira LMA, Gasser T, Edwards R, Zweckstetter M, Melki R, Stefanis L, Lashuel HA, Sulzer D, Vekrellis K, Halliday GM, Tomlinson JJ, Schlossmacher M, Jensen PH, Schulze-Hentrich J, Riess O, Hirst WD, El-Agnaf O, Mollenhauer B, Lansbury P, Outeiro TF.<
NPJ Parkinsons Dis. 2021 Jul 26;7(1):65. doi: 10.1038/s41531-021-00203-9.
PubMed

In silico analysis of the aggregation propensity of the SARS-CoV-2 proteome: Insight into possible cellular pathologies.
Flores-León M, Lázaro DF, Shvachiy L, Krisko A, Outeiro TF.
Biochim Biophys Acta Proteins Proteom. 2021 Oct;1869(10):140693. doi: 10.1016/j.bbapap.2021.140693. Epub 2021 Jul 5.
PubMed

Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies.
Miranda HV, Szegő ÉM, Oliveira LMA, Breda C, Darendelioglu E, de Oliveira RM, Ferreira DG, Gomes MA, Rott R, Oliveira M, Munari F, Enguita FJ, Simões T, Rodrigues EF, Heinrich M, Martins IC, Zamolo I, Riess O, Cordeiro C, Ponces-Freire A, Lashuel HA, Santos NC, Lopes LV, Xiang W, Jovin TM, Penque D, Engelender S, Zweckstetter M, Klucken J, Giorgini F, Quintas A, Outeiro TF.
Brain. 2021 Jul 28;144(6):e58. doi: 10.1093/brain/awab175.
PubMed

Cerebral dopamine neurotrophic factor reduces α-synuclein aggregation and propagation and alleviates behavioral alterations in vivo.
Albert K, Raymundo DP, Panhelainen A, Eesmaa A, Shvachiy L, Araújo GR, Chmielarz P, Yan X, Singh A, Cordeiro Y, Palhano FL, Foguel D, Luk KC, Domanskyi A, Voutilainen MH, Huttunen HJ,Outeiro TF, Saarma M, Almeida MS, Airavaara M.
Mol Ther. 2021 Sep 1;29(9):2821-2840. doi: 10.1016/j.ymthe.2021.04.035. Epub 2021 May 1.
PubMed

Dysfunction of RAB39B-Mediated Vesicular Trafficking in Lewy Body Diseases.
Koss DJ, Campesan S, Giorgini F, Outeiro TF.
Mov Disord. 2021 Aug;36(8):1744-1758. doi: 10.1002/mds.28605. Epub 2021 May 3.
PubMed

Identification of Two Novel Peptides That Inhibit α-Synuclein Toxicity and Aggregation.
Popova B, Wang D, Rajavel A, Dhamotharan K, Lázaro DF, Gerke J, Uhrig JF, Hoppert M, Outeiro TF, Braus GH.
Front Mol Neurosci. 2021 Apr 12;14:659926. doi: 10.3389/fnmol.2021.659926. eCollection 2021.
PubMed

Doxycycline Interferes With Tau Aggregation and Reduces Its Neuronal Toxicity.
Medina L, González-Lizárraga F, Dominguez-Meijide A, Ploper D, Parrales V, Sequeira S, Cima-Omori MS, Zweckstetter M, Del Bel E, Michel PP, Outeiro TF, Raisman-Vozari R, Chehín R, Socias SB.
Front Aging Neurosci. 2021 Mar 22;13:635760. doi: 10.3389/fnagi.2021.635760. eCollection 2021.
PubMed

The Neuroprotective Action of Amidated-Kyotorphin on Amyloid β Peptide-Induced Alzheimer’s Disease Pathophysiology.
Belo RF, Martins MLF, Shvachiy L, Costa-Coelho T, de Almeida-Borlido C, Fonseca-Gomes J, Neves V, Vicente Miranda H, Outeiro TF, Coelho JE, Xapelli S, Valente CA, Heras M, Bardaji E, Castanho MARB, Diógenes MJ, Sebastião AM.
Front Pharmacol. 2020 Jul 9;11:985. doi: 10.3389/fphar.2020.00985. eCollection 2020.
PubMed

Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization.
Dominguez-Meijide A, Vasili E, König A, Cima-Omori MS, Ibáñez de Opakua A, Leonov A, Ryazanov S, Zweckstetter M, Griesinger C, Outeiro TF
Sci Rep. 2020 Jul 30;10(1):12827. doi: 10.1038/s41598-020-69744-y.
PubMed

Reply to: SARS-CoV-2 as a Potential Trigger of Neurodegenerative Diseases.
Outeiro TF, Krisko A.
Mov Disord. 2020 Jul;35(7):1106-1107. doi: 10.1002/mds.28178.
PubMed

Protein trapping leads to altered synaptic proteostasis in synucleinopathies.
Santos PI, Outeiro TF
FEBS J. 2020 Dec;287(24):5294-5303. doi: 10.1111/febs.15364. Epub 2020 May 23.
PubMed

X1INH, an improved next-generation affinity-optimized hydrazonic ligand, attenuates abnormal copper(I)/copper(II)-α-Syn interactions and affects protein aggregation in a cellular model of synucleinopathy.
Cukierman DS , Lázaro DF , Sacco P , Ferreira PR , Diniz R , Fernández CO , Outeiro TF , Rey NA .
Dalton Trans. 2020 Nov 25;49(45):16252-16267. doi: 10.1039/d0dt01138j.
PubMed

SARS-CoV-2: At the Crossroad Between Aging and Neurodegeneration.
Lippi A, Domingues R, Setz C, Outeiro TF, Krisko A.
Mov Disord. 2020 May;35(5):716-720. doi: 10.1002/mds.28084. Epub 2020 Apr 24.
PubMed

The Interplay Between Proteostasis Systems and Parkinson’s Disease.
Lázaro DF, Outeiro TF
Adv Exp Med Biol. 2020;1233:223-236. doi: 10.1007/978-3-030-38266-7_9.
PubMed

Inhibition of HDAC6 activity protects dopaminergic neurons from alpha-synuclein toxicity.
Francelle L, Outeiro TF, Rappold GA.
Sci Rep. 2020 Apr 8;10(1):6064. doi: 10.1038/s41598-020-62678-5.
PubMed

Hsp27 reduces glycation-induced toxicity and aggregation of alpha-synuclein.
Vicente Miranda H, Chegão A, Oliveira MS, Fernandes Gomes B, Enguita FJ, Outeiro TF.
FASEB J. 2020 May;34(5):6718-6728. doi: 10.1096/fj.201902936R. Epub 2020 Apr 7.
PubMed

Mechanisms of alpha-synuclein toxicity: An update and outlook.
Brás IC, Xylaki M, Outeiro TF.
Prog Brain Res. 2020;252:91-129. doi: 10.1016/bs.pbr.2019.10.005. Epub 2019 Nov 23
PubMed

The courage to change science.
Outeiro TF.
EMBO Rep. 2020 Mar 4;21(3):e50124. doi: 10.15252/embr.202050124. Epub 2020 Feb 20.
PubMed

A new MAP-Rasagiline conjugate reduces α-synuclein inclusion formation in a cell model.
Vale N, Alves C, Sharma V, Lázaro DF, Silva S, Gomes P, Outeiro TF.
Pharmacol Rep. 2020 Jan 15. doi: 10.1007/s43440-019-00032-x. [Epub ahead of print] PubMed

Editorial: Protein Misfolding and Spreading Pathology in Neurodegenerative Diseases.
Lázaro DF, Bellucci A, Brundin P, Outeiro TF.
Front Mol Neurosci. 2020 Jan 17;12:312. doi: 10.3389/fnmol.2019.00312. eCollection 2019. No abstract available.
PubMed

Synucleinopathies: Where we are and where we need to go.
Brás IC, Dominguez-Meijide A, Gerhardt E, Koss D, Lázaro DF, Santos PI, Vasili E, Xylaki M, Outeiro TF.
J Neurochem. 2020 Jan 20. doi: 10.1111/jnc.14965. [Epub ahead of print] Review.
PubMed

Identification of antiparkinsonian drugs in the 6-hydroxydopamine zebrafish model.
Vaz RL, Sousa S, Chapela D, van der Linde HC, Willemsen R, Correia AD, Outeiro TF, Afonso ND.
Pharmacol Biochem Behav. 2020 Feb;189:172828. doi: 10.1016/j.pbb.2019.172828. Epub 2019 Nov 28.
PubMed

Tapentadol Prevents Motor Impairments in a Mouse Model of Dyskinesia.
Vaz RL, Chapela D, Coelho JE, Lopes LV, Ferreira JJ, Afonso ND, Sousa S, Outeiro TF.
Neuroscience. 2020 Jan 1;424:58-71. doi: 10.1016/j.neuroscience.2019.08.046. Epub 2019 Nov 1.
PubMed

Molecular characterization of an aggregation-prone variant of alpha-synuclein used to model synucleinopathies.
Masaracchia C, König A, Valiente-Gabioud AA, Peralta P, Favretto F, Strohäker T, Lázaro DF, Zweckstetter M, Fernandez CO, Outeiro TF.
Biochim Biophys Acta Proteins Proteom. 2020 Jan;1868(1):140298. doi: 10.1016/j.bbapap.2019.140298. Epub 2019
PubMed

Are genetic and idiopathic forms of Parkinson’s disease the same disease?
Correia Guedes L, Mestre T, Outeiro TF, Ferreira JJ.
J Neurochem. 2020 Mar;152(5):515-522. doi: 10.1111/jnc.14902. Epub 2019 Dec 8. Review.
PubMed

Characterization of the activity, aggregation, and toxicity of heterodimers of WT and ALS-associated mutant Sod1.
Brasil AA, de Carvalho MDC, Gerhardt E, Queiroz DD, Pereira MD, Outeiro TF, Eleutherio ECA.
Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):25991-26000. doi: 10.1073/pnas.1902483116. Epub 2019 Dec 3.
PubMed

Synuclein Meeting 2019: where we are and where we need to go.
Outeiro TF, Mestre TA.
J Neurochem. 2019 Sep;150(5):462-466. doi: 10.1111/jnc.14825.
PubMed

Epigenetics of the Synapse in Neurodegeneration.
Xylaki M, Atzler B, Outeiro TF.
Curr Neurol Neurosci Rep. 2019 Aug 23;19(10):72. doi: 10.1007/s11910-019-0995-y. Review.
PubMed

The synthetic cannabinoid JWH-018 modulates Saccharomyces cerevisiae energetic metabolism.
Ferreira C, Couceiro J, Família C, Jardim C, Antas P, Santos CN, Outeiro TF, Tenreiro S, Quintas A.
FEMS Yeast Res. 2019 Aug 1;19(5). pii: foz042. doi: 10.1093/femsyr/foz042.
PubMed

A_2A R-induced transcriptional deregulation in astrocytes: An in vitro study.
Paiva I, Carvalho K, Santos P, Cellai L, Pavlou MAS, Jain G, Gnad T, Pfeifer A, Vieau D, Fischer A, Buée L, Outeiro TF, Blum D.
Glia. 2019 Dec;67(12):2329-2342. doi: 10.1002/glia.23688. Epub 2019 Jul 22.
PubMed

Glycation in Huntington’s Disease: A Possible Modifier and Target for Intervention.
Brás IC, König A, Outeiro TF.
J Huntingtons Dis. 2019;8(3):245-256. doi: 10.3233/JHD-190366.
PubMed

Cytosolic Trapping of a Mitochondrial Heat Shock Protein Is an Early Pathological Event in Synucleinopathies.
Szegő ÉM, Dominguez-Meijide A, Gerhardt E, König A, Koss DJ, Li W, Pinho R, Fahlbusch C, Johnson M, Santos P, Villar-Piqué A, Thom T, Rizzoli S, Schmitz M, Li J, Zerr I, Attems J, Jahn O, Outeiro TF.
Cell Rep. 2019 Jul 2;28(1):65-77.e6. doi: 10.1016/j.celrep.2019.06.009.
PubMed

Cellular models of alpha-synuclein toxicity and aggregation.
Delenclos M, Burgess JD, Lamprokostopoulou A, Outeiro TF, Vekrellis K, McLean PJ.
J Neurochem. 2019 Sep;150(5):566-576. doi: 10.1111/jnc.14806. Epub 2019 Jul 30. Review.
PubMed

Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy.
Wu JZ, Ardah M, Haikal C, Svanbergsson A, Diepenbroek M, Vaikath NN, Li W, Wang ZY, Outeiro TF, El-Agnaf OM, Li JY.
Transl Neurodegener. 2019 Jun 15;8:18. doi: 10.1186/s40035-019-0159-7. eCollection 2019.
PubMed

Spreading of α-Synuclein and Tau: A Systematic Comparison of the Mechanisms Involved.
Vasili E, Dominguez-Meijide A, Outeiro TF.
Front Mol Neurosci. 2019 Apr 25;12:107. doi: 10.3389/fnmol.2019.00107. eCollection 2019. Review.
PubMed

Effects of alpha-synuclein posttranslational modifications on metal binding.
González N, Arcos-López T, König A, Quintanar L, Menacho Márquez M, Outeiro TF, Fernández CO.
J Neurochem. 2019 May 16. doi: 10.1111/jnc.14721. [Epub ahead of print] Review.
PubMed

LRRK2, alpha-synuclein, and tau: partners in crime or unfortunate bystanders?
Outeiro TF, Harvey K, Dominguez-Meijide A, Gerhardt E.
Biochem Soc Trans. 2019 May 13. pii: BST20180466. doi: 10.1042/BST20180466. [Epub ahead of print] Review.
PubMed

Investigating targets for neuropharmacological intervention by molecular dynamics simulations.
Rossetti G, Kless A, Lai L, Outeiro TF, Carloni P.
Biochem Soc Trans. 2019 May 13. pii: BST20190048. doi: 10.1042/BST20190048. [Epub ahead of print] Review.
PubMed

In vitro models of synucleinopathies: informing on molecular mechanisms and protective strategies.
Marvian AT, Koss DJ, Aliakbari F, Morshedi D, Outeiro TF.
J Neurochem. 2019 Apr 20. doi: 10.1111/jnc.14707. [Epub ahead of print] Review.
PubMed

α-Synuclein toxicity in yeast and human cells is caused by cell cycle re-entry and autophagy degradation of ribonucleotide reductase 1.
Sampaio-Marques B, Guedes A, Vasilevskiy I, Gonçalves S, Outeiro TF, Winderickx J, Burhans WC, Ludovico P.
Aging Cell. 2019 Apr 11:e12922. doi: 10.1111/acel.12922. [Epub ahead of print] PubMed

Seeding variability of different alpha synuclein strains in synucleinopathies.
Candelise N, Schmitz M, Llorens F, Villar-Piqué A, Cramm M, Thom T, da Silva Correia SM, da Cunha JEG, Möbius W, Outeiro TF, Álvarez VG, Banchelli M, D’Andrea C, de Angelis M, Zafar S, Rabano A, Matteini P, Zerr I.
Ann Neurol. 2019 May;85(5):691-703. doi: 10.1002/ana.25446. Epub 2019 Mar 27.
PubMed

Translocator protein ligand protects against neurodegeneration in the MPTP mouse model of Parkinsonism.
Gong J, Szegő ÉM, Leonov A, Benito E, Becker S, Fischer A, Zweckstetter M, Outeiro T, Schneider A.
J Neurosci. 2019 Feb 22. pii: 2070-18. doi: 10.1523/JNEUROSCI.2070-18.2019. [Epub ahead of print] PubMed

Yeast-Based Screens to Target Alpha-Synuclein Toxicity.
Brás IC, Popova B, Braus GH, Outeiro TF.
Methods Mol Biol. 2019;1948:145-156. doi: 10.1007/978-1-4939-9124-2_12.
PubMed

Biasing the native α-synuclein conformational ensemble towards compact states abolishes aggregation and neurotoxicity.
Carija A, Pinheiro F, Pujols J, Brás IC, Lázaro DF, Santambrogio C, Grandori R, Outeiro TF, Navarro S, Ventura S.
Redox Biol. 2019 Apr;22:101135. doi: 10.1016/j.redox.2019.101135. Epub 2019 Feb 5.
PubMed

Dementia with Lewy bodies: an update and outlook.
Outeiro TF, Koss DJ, Erskine D, Walker L, Kurzawa-Akanbi M, Burn D, Donaghy P, Morris C, Taylor JP, Thomas A, Attems J, McKeith I.
Mol Neurodegener. 2019 Jan 21;14(1):5. doi: 10.1186/s13024-019-0306-8. Review.
PubMed

The role of LRRK2 in cell signalling.
Harvey K, Outeiro TF.
Biochem Soc Trans. 2019 Feb 28;47(1):197-207. doi: 10.1042/BST20180464. Epub 2018 Dec 21. Review.
PubMed

Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding.
Chiang AN, Liang M, Dominguez-Meijide A, Masaracchia C, Goeckeler-Fried JL, Mazzone CS, Newhouse DW, Kendsersky NM, Yates ME, Manos-Turvey A, Needham PG, Outeiro TF, Wipf P, Brodsky JL.
Bioorg Med Chem. 2019 Jan 1;27(1):79-91. doi: 10.1016/j.bmc.2018.11.011. Epub 2018 Nov 15.
PubMed

Monitoring α-synuclein multimerization in vivo.
Prasad V, Wasser Y, Hans F, Goswami A, Katona I, Outeiro TF, Kahle PJ, Schulz JB, Voigt A
FASEB J. 2018 Sep 25:fj201800148RRR. doi: 10.1096/fj.201800148RRR.
PubMed

The Parkinson’s Disease-Linked Protein DJ-1 Associates with Cytoplasmic mRNP Granules During Stress and Neurodegeneration.
Repici M, Hassanjani M, Maddison DC, Garção P, Cimini S, Patel B, Szegö ÉM, Straatman KR, Lilley KS, Borsello T, Outeiro TF, Panman L, Giorgini F.
Mol Neurobiol. 2018 Apr 19. doi: 10.1007/s12035-018-1084-y. [Epub ahead of print] PubMed

The role of LRRK2 in cell signalling.
Harvey K, Outeiro TF.
Biochem Soc Trans. 2018 Dec 21. pii: BST20180464. doi: 10.1042/BST20180464. [Epub ahead of print] Review.
PubMed

Sensing α-Synuclein From the Outside via the Prion Protein: Implications for Neurodegeneration.
Brás IC, Lopes LV, Outeiro TF.
Mov Disord. 2018 Nov;33(11):1675-1684. doi: 10.1002/mds.27478. Epub 2018 Nov 13.
PubMed

Secretion and Uptake of α-Synuclein Via Extracellular Vesicles in Cultured Cells.
Gustafsson G, Lööv C, Persson E, Lázaro DF, Takeda S, Bergström J, Erlandsson A, Sehlin D, Balaj L, György B, Hallbeck M, Outeiro TF, Breakefield XO, Hyman BT, Ingelsson M.
Cell Mol Neurobiol. 2018 Nov;38(8):1539-1550. doi: 10.1007/s10571-018-0622-5. Epub 2018 Oct 4.
PubMed

Identification of novel protein phosphatases as modifiers of alpha-synuclein aggregation in yeast.
Brás IC, Tenreiro S, Silva AM, Outeiro TF.
FEMS Yeast Res. 2018 Oct 1. doi: 10.1093/femsyr/foy108.
PubMed

Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons.
Pujols J, Peña-Díaz S, Lázaro DF, Peccati F, Pinheiro F, González D, Carija A, Navarro S, Conde-Giménez M, García J, Guardiola S, Giralt E, Salvatella X, Sancho J, Sodupe M, Outeiro TF, Dalfó E, Ventura S.
Proc Natl Acad Sci U S A. 2018 Sep 24. pii: 201804198. doi: 10.1073/pnas.1804198115.
PubMed

Nuclear localization and phosphorylation modulate pathological effects of Alpha-Synuclein.
Pinho R, Paiva I, Jercic KG, Fonseca-Ornelas L, Gerhardt E, Fahlbusch C, Garcia-Esparcia P, Kerimoglu C, Pavlou MA, Villar-Piqué A, Szego É, Fonseca TL, Odoardi F, Soeroes S, Rego AC, Fischle W, Schwamborn JC, Meyer T, Kügler S, Ferrer I, Attems J, Fischer A, Becker S, Zweckstetter M, Borovecki F, Outeiro TF.
Hum Mol Genet. 2018 Sep 13. doi: 10.1093/hmg/ddy326.
PubMed

Membrane binding, internalization, and sorting of alpha-synuclein in the cell.
Masaracchia C, Hnida M, Gerhardt E, Lopes da Fonseca T, Villar-Pique A, Branco T, Stahlberg MA, Dean C, Fernández CO, Milosevic I, Outeiro TF.
Acta Neuropathol Commun. 2018 Aug 14;6(1):79. doi: 10.1186/s40478-018-0578-1.
PubMed

Alpha-synuclein deregulates the expression of COL4A2 and impairs ER-Golgi function.
Paiva I, Jain G, Lázaro DF, Jerčić KG, Hentrich T, Kerimoglu C, Pinho R, Szegő ÈM, Burkhardt S, Capece V, Halder R, Islam R, Xylaki M, Caldi Gomes LA, Roser AE, Lingor P, Schulze-Hentrich JM, Borovečki F, Fischer A, Outeiro TF.
Neurobiol Dis. 2018 Aug 6;119:121-135. doi: 10.1016/j.nbd.2018.08.001. [Epub ahead of print] PubMed

The trehalose protective mechanism during thermal stress in Saccharomyces cerevisiae: the roles of Ath1 and Agt1.
Magalhães RSS, Popova B, Braus GH, Outeiro TF, Eleutherio ECA.
FEMS Yeast Res. 2018 Sep 1;18(6). doi: 10.1093/femsyr/foy066.
PubMed

Age-related shift in LTD is dependent on neuronal adenosine A_2A receptors interplay with mGluR5 and NMDA receptors.
Temido-Ferreira M, Ferreira DG, Batalha VL, Marques-Morgado I, Coelho JE, Pereira P, Gomes R, Pinto A, Carvalho S, Canas PM, Cuvelier L, Buée-Scherrer V, Faivre E, Baqi Y, Müller CE, Pimentel J, Schiffmann SN, Buée L, Bader M, Outeiro TF, Blum D, Cunha RA, Marie H, Pousinha PA, Lopes LV.
Mol Psychiatry. 2018 Jun 27. doi: 10.1038/s41380-018-0110-9. [Epub ahead of print] PubMed

Zebrafish as an Animal Model for Drug Discovery in Parkinson’s Disease and Other Movement Disorders: A Systematic Review.
Vaz RL, Outeiro TF, Ferreira JJ.
Front Neurol. 2018 Jun 1;9:347. doi: 10.3389/fneur.2018.00347. eCollection 2018.
PubMed

(Poly)phenol-digested metabolites modulate alpha-synuclein toxicity by regulating proteostasis.
Macedo D, Jardim C, Figueira I, Almeida AF, McDougall GJ, Stewart D, Yuste JE, Tomás-Barberán FA, Tenreiro S, Outeiro TF, Santos CN.
Sci Rep. 2018 May 3;8(1):6965. doi: 10.1038/s41598-018-25118-z.
PubMed

The Parkinson’s Disease-Linked Protein DJ-1 Associates with Cytoplasmic mRNP Granules During Stress and Neurodegeneration.
Repici M, Hassanjani M, Maddison DC, Garção P, Cimini S, Patel B, Szegö ÉM, Straatman KR, Lilley KS, Borsello T, Outeiro TF, Panman L, Giorgini F.
Mol Neurobiol. 2018 Apr 19. doi: 10.1007/s12035-018-1084-y. [Epub ahead of print] PubMed

Diabetes Mellitus as a Risk Factor for Parkinson’s Disease: a Molecular Point of View.
Biosa A, Outeiro TF, Bubacco L, Bisaglia M.
Mol Neurobiol. 2018 Mar 28. doi: 10.1007/s12035-018-1025-9. [Epub ahead of print] Review.
PubMed

Binding Modes of Phthalocyanines to Amyloid β Peptide and Their Effects on Amyloid Fibril Formation.
Valiente-Gabioud AA, Riedel D, Outeiro TF, Menacho-Márquez MA, Griesinger C, Fernández CO.
Biophys J. 2018 Mar 13;114(5):1036-1045. doi: 10.1016/j.bpj.2018.01.003.
PubMed

SIRT2 in age-related neurodegenerative disorders.
Fourcade S, Outeiro TF, Pujol A.
Aging. 2018 Mar 3;10(3):295-296. doi: 10.18632/aging/101397. No abstract available.
PubMed

Alpha-Synuclein Glycation and the Action of Anti-Diabetic Agents in Parkinson’s Disease.
König A, Vicente Miranda H, Outeiro TF.
J Parkinsons Dis. 2018;8(1):33-43. doi: 10.3233/JPD-171285.
PubMed

Guidelines and recommendations on yeast cell death nomenclature.
Carmona-Gutierrez D, Bauer MA, Zimmermann A, Aguilera A, Austriaco N, Ayscough K, Balzan R, Bar-Nun S, Barrientos A, Belenky P, Blondel M, Braun RJ, Breitenbach M, Burhans WC, Büttner S, Cavalieri D, Chang M, Cooper KF, Côrte-Real M, Costa V, Cullin C, Dawes I, Dengjel J, Dickman MB, Eisenberg T, Fahrenkrog B, Fasel N, Fröhlich KU, Gargouri A, Giannattasio S, Goffrini P, Gourlay CW, Grant CM, Greenwood MT, Guaragnella N, Heger T, Heinisch J, Herker E, Herrmann JM, Hofer S, Jiménez-Ruiz A, Jungwirth H, Kainz K, Kontoyiannis DP, Ludovico P, Manon S, Martegani E, Mazzoni C, Megeney LA, Meisinger C, Nielsen J, Nyström T, Osiewacz HD, Outeiro TF, Park HO, Pendl T, Petranovic D, Picot S, Polčic P, Powers T, Ramsdale M, Rinnerthaler M, Rockenfeller P, Ruckenstuhl C, Schaffrath R, Segovia M, Severin FF, Sharon A, Sigrist SJ, Sommer-Ruck C, Sousa MJ, Thevelein JM, Thevissen K, Titorenko V, Toledano MB, Tuite M, Vögtle FN, Westermann B, Winderickx J, Wissing S, Wölfl S, Zhang ZJ, Zhao RY, Zhou B, Galluzzi L, Kroemer G, Madeo F. Microbial cell (Graz, Austria). 2018 Jan 1;5(1):4-31. doi: 10.15698/mic2018.01.607. Review.
PubMed

Attention-deficit/hyperactivity disorder is associated with reduced levels of serum low-density lipoprotein cholesterol in adolescents. Data from the population-based German KiGGS study.
Pinho R, Wang B, Becker A, Rothenberger A, Outeiro TF, Herrmann-Lingen C, Meyer T.
World J Biol Psychiatry. 2018 Jan 11:1-9. doi: 10.1080/15622975.2017.1417636. [Epub ahead of print] PubMed

Glyoxal as an alternative fixative to formaldehyde in immunostaining and super-resolution microscopy.
Richter KN, Revelo NH, Seitz KJ, Helm MS, Sarkar D, Saleeb RS, D’Este E, Eberle J, Wagner E, Vogl C, Lazaro DF, Richter F, Coy-Vergara J, Coceano G, Boyden ES, Duncan RR, Hell SW, Lauterbach MA, Lehnart SE, Moser T, Outeiro TF, Rehling P, Schwappach B, Testa I, Zapiec B, Rizzoli SO.
EMBO J. 2018 Jan 4;37(1):139-159. doi: 10.15252/embj.201695709. Epub 2017 Nov 16.
PubMed

IGF-I Gene Therapy in Aging Rats Modulates Hippocampal Genes Relevant to Memory Function.
Pardo J, Abba MC, Lacunza E, Ogundele OM, Paiva I, Morel GR, Outeiro TF, Goya RG.
J Gerontol A Biol Sci Med Sci. 2018 Mar 14;73(4):459-467. doi: 10.1093/gerona/glx125.
PubMed

Correction: Gene Expression Differences in Peripheral Blood of Parkinson’s Disease Patients with Distinct Progression Profiles.
Pinho R, Guedes LC, Soreq L, Lobo PP, Mestre T, Coelho M, Rosa MM, Gonçalves N, Wales P, Mendes T, Gerhardt E, Fahlbusch C, Bonifati V, Bonin M, Miltenberger-Miltényi G, Borovecki F, Soreq H, Ferreira JJ, Outeiro TF.
PLoS One. 2017 Dec 28;12(12):e0190552. doi: 10.1371/journal.pone.0190552. eCollection 2017.
PubMed

Attention-deficit/hyperactivity disorder is associated with reduced levels of serum low-density lipoprotein cholesterol in adolescents. Data from the population-based German KiGGS study.
Pinho R, Wang B, Becker A, Rothenberger A, Outeiro TF, Herrmann-Lingen C, Meyer T.
World J Biol Psychiatry. 2018 Jan 11:1-9. doi: 10.1080/15622975.2017.1417636. [Epub ahead of print].
PubMed

The influence of dopamine-beta-hydroxylase and catechol O-methyltransferase gene polymorphism on the efficacy of insulin detemir therapy in patients with type 2 diabetes mellitus.
Bozek T, Blazekovic A, Perkovic MN, Jercic KG, Sustar A, Smircic-Duvnjak L, Outeiro TF, Pivac N, Borovecki F.
Diabetol Metab Syndr. 2017 Dec 4;9:97. doi: 10.1186/s13098-017-0295-0. eCollection 2017.
PubMed

Glyoxal as an alternative fixative to formaldehyde in immunostaining and super-resolution microscopy.
Richter KN, Revelo NH, Seitz KJ, Helm MS, Sarkar D, Saleeb RS, D’Este E, Eberle J, Wagner E, Vogl C, Lazaro DF, Richter F, Coy-Vergara J, Coceano G, Boyden ES, Duncan RR, Hell SW, Lauterbach MA, Lehnart SE, Moser T, Outeiro TF, Rehling P, Schwappach B, Testa I, Zapiec B, Rizzoli SO.
The EMBO journal. 2018 Jan 4;37(1):139-159. doi: 10.15252/embj.201695709. Epub 2017 Nov 16.
PubMed

Building Bridges through Science.
Lissek T, Adams M, Adelman J, Ahissar E, Akaaboune M, Akil H, al’Absi M, Arain F, Arango-Lasprilla JC, Atasoy D, Avila J, Badawi A, Bading H, Baig AM, Baleriola J, Belmonte C, Bertocchi I, Betz H, Blakemore C, Blanke O, Boehm-Sturm P, Bonhoeffer T, Bonifazi P, Brose N, Campolongo P, Celikel T, Chang CC, Chang TY, Citri A, Cline HT, Cortes JM, Cullen K, Dean K, Delgado-Garcia JM, Desroches M, Disterhoft JF, Dowling JE, Draguhn A, El-Khamisy SF, El Manira A, Enam SA, Encinas JM, Erramuzpe A, Esteban JA, Fariñas I, Fischer E, Fukunaga I, Gabilondo I, Ganten D, Gidon A, Gomez Esteban JC, Greengard P, Grinevich V, Gruart A, Guillemin R, Hariri AR, Hassan B, Häusser M, Hayashi Y, Hussain NK, Jabbar AA, Jaber M, Jahn R, Janahi EM, Kabbaj M, Kettenmann H, Kindt M, Knafo S, Köhr G, Komai S, Krugers H, Kuhn B, Ghazal NL, Larkum ME, London M, Lutz B, Matute C, Martinez-Millan L, Maroun M, McGaugh J, Moustafa AA, Nasim A, Nave KA, Neher E, Nikolich K, Outeiro T, Palmer LM, Penagarikano O, Perez-Otano I, Pfaff DW, Poucet B, Rahman AU, Ramos-Cabrer P, Rashidy-Pour A, Roberts RJ, Rodrigues S, Sanes JR, Schaefer AT, Segal M, Segev I, Shafqat S, Siddiqui NA, Soreq H, Soriano-García E, Spanagel R, Sprengel R, Stuart G, Südhof TC, Tønnesen J, Treviño M, Uthman BM, Venter JC, Verkhratsky A, Weiss C, Wiesel TN, Yaksi E, Yizhar O, Young LJ, Young P, Zawia NH, Zugaza JL, Hasan MT.
Neuron. 2017 Nov 15;96(4):730-735. doi: 10.1016/j.neuron.2017.09.028.
PubMed

Editorial: Molecular Chaperones and Neurodegeneration.
Roodveldt C, Outeiro TF, Braun JEA.
Front Neurosci. 2017 Oct 11;11:565. doi:10.3389/fnins.2017.00565. eCollection 2017.
PubMed

Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson’s disease..
Vicente Miranda H, Cássio R, Correia-Guedes L, Gomes MA, Chegão A, Miranda E, Soares T, Coelho M, Rosa MM, Ferreira JJ, Outeiro TF.
Sci Rep. 2017 Oct 20;7(1):13713. doi:10.1038/s41598-017-14175-5.
PubMed

The NAD+-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes.
Lemos V, de Oliveira RM, Naia L, Szegö É, Ramos E, Pinho S, Magro F, Cavadas C, Rego AC, Costa V, Outeiro TF, Gomes P.
Hum Mol Genet. 2017 Nov 1;26(21):4105-4117. doi: 10.1093/hmg/ddx298.
PubMed

α-synuclein interacts with PrP(C) to induce cognitive impairment through mGluR5 and NMDAR2B..
Ferreira DG, Temido-Ferreira M, Miranda HV, Batalha VL, Coelho JE, Szegö ÉM, Marques-Morgado I, Vaz SH, Rhee JS, Schmitz M, Zerr I, Lopes LV, Outeiro TF.
Nat Neurosci. 2017 Nov;20(11):1569-1579. doi: 10.1038/nn.4648. Epub 2017 Sep 25.
PubMed

Protein phosphatase 1 regulates huntingtin exon 1 aggregation andtoxicity.
Branco-Santos J, Herrera F, Poças GM, Pires-Afonso Y, Giorgini F, Domingos PM, Outeiro TF
Hum Mol Genet. 2017 Oct 1;26(19):3763-3775. doi: 10.1093/hmg/ddx260.
PubMed

Cell Reprogramming: Theraoeutic potential and the promise of Rejuvenation for the Aging Brain.
López-León M, Outeiro TF, Goya RG.
Ageing Res Rev. 2017 Sep 10. pii: S1568-1637(17)30018-1. doi: 10.1016/j.arr.2017.09.002.Review.
PubMed

Serum lipid alterations in GBA-associated Parkinson’s disease..
Guedes LC, Chan RB, Gomes MA, Conceição VA, Machado RB, Soares T, Xu Y, Gaspar P, Carriço JA, Alcalay RN, Ferreira JJ, Outeiro TF, Miltenberger-Miltenyi G.
Parkinsonism Relat Disord. 2017 Sep 1. pii: S1353-8020(17)30322-X. doi: 10.1016/j.parkreldis.2017.08.026.
PubMed

Implications of fALS Mutations on Sod1 Function and Oligomerization in Cell Models..
Brasil AA, Magalhães RSS, De Carvalho MDC, Paiva I, Gerhardt E, Pereira MD, Outeiro TF, Eleutherio ECA.
Mol Neurobiol. 2017 Sep 7. doi: 10.1007/s12035-017-0755-4.
PubMed

Neuromelanin magnetic resonance imaging of the substantia nigra in LRRK2-relatedParkinson’s disease..
Correia Guedes L, Reimão S, Paulino P, Nunes RG, Bouça-Machado R, Abreu D, Gonçalves N, Soares T, Fabbri M, Godinho C, Pita Lobo P, Neutel D, Quadri M, Coelho M, Rosa MM, Campos J, Outeiro TF, Sampaio C, Bonifati V, Ferreira JJ.
Mov Disord. 2017 Sep;32(9):1331-1333. doi: 10.1002/mds.27083. Epub 2017 Jul 7.
PubMed

Tau deletion promotes brain insulin resistance.
Marciniak E, Leboucher A, Caron E, Ahmed T, Tailleux A, Dumont J, Issad T, Gerhardt E, Pagesy P, Vileno M, Bournonville C, Hamdane M, Bantubungi K, Lancel S, Demeyer D, Eddarkaoui S, Vallez E, Vieau D, Humez S, Faivre E, Grenier-Boley B, Outeiro TF, Staels B, Amouyel P, Balschun D, Buee L, Blum D.
The Journal of experimental medicine. 2017 Aug 7;214(8):2257-2269. doi: 10.1084/jem.20161731. Epub 2017 Jun 26.
PubMed

IGF-I Gene Therapy in Aging Rats Modulates Hippocampal Genes Relevant to Memory Function.
Pardo J, Abba MC, Lacunza E, Ogundele OM, Paiva I, Morel GR, Outeiro TF, Goya RG. J Gerontol A Biol Sci Med Sci. 2017 Jun 22. doi:
10.1093/gerona/glx125. [Epub ahead of print] PubMed

Treatment with diphenyl-pyrazole compound anle138b/c reveals that α-synuclein protects melanoma cells from autophagic cell death.
Turriani E, Lázaro DF, Ryazanov S, Leonov A, Giese A, Schön M, Schön MP, Griesinger C, Outeiro TF, Arndt-Jovin DJ, Becker D.
Proceedings of the National Academy of Sciences of the United States of America. 2017 Jun 20;114(25):E4971-E4977. doi: 10.1073/pnas.1700200114. Epub 2017 Jun 5.
PubMed

Nrf2 activation by tauroursodeoxycholic acid in experimental models of Parkinson’s disease.
Moreira S, Fonseca I, Nunes MJ, Rosa A, Lemos L, Rodrigues E, Carvalho AN, Outeiro TF, Rodrigues CMP, Gama MJ, Castro-Caldas M.
Experimental neurology. 2017 Sep;295:77-87. doi: 10.1016/j.expneurol.2017.05.009. Epub 2017 May 25.
PubMed

Cellular models as tools for the study of the role of alpha-synuclein in Parkinson’s disease.
Lázaro DF, Pavlou MAS, Outeiro TF.
Experimental neurology. 2017 Dec;298(Pt B):162-171. doi: 10.1016/j.expneurol.2017.05.007. Epub 2017 May 16. Review.
PubMed

Epigenetics in Parkinson’s Disease.
Pavlou MAS, Outeiro TF.
Advances in experimental medicine and biology. 2017;978:363-390. doi: 10.1007/978-3-319-53889-1_19. Review.
PubMed

Sirtuin 2 enhances dopaminergic differentiation via the AKT/GSK-3β/β-catenin pathway.
Szegő ÉM, Gerhardt E, Outeiro TF.
Neurobiology of aging. 2017 Aug;56:7-16. doi: 10.1016/j.neurobiolaging.2017.04.001. Epub 2017 Apr 10.
PubMed

Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies.
Vicente Miranda H, Szego ÉM, Oliveira LMA, Breda C, Darendelioglu E, de Oliveira RM, Ferreira DG, Gomes MA, Rott R, Oliveira M, Munari F, Enguita FJ, Simões T, Rodrigues EF, Heinrich M, Martins IC, Zamolo I, Riess O, Cordeiro C, Ponces-Freire A, Lashuel HA, Santos NC, Lopes LV, Xiang W, Jovin TM, Penque D, Engelender S, Zweckstetter M, Klucken J, Giorgini F, Quintas A, Outeiro TF.
Brain : a journal of neurology. 2017 May 1;140(5):1399-1419. doi: 10.1093/brain/awx056.
PubMed

Correction: The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.
de Oliveira RM, Vicente Miranda H, Francelle L, Pinho R, Szegö ÉM, Martinho R, Munari F, Lázaro DF, Moniot S, Guerreiro P, Fonseca-Ornelas L, Marijanovic Z, Antas P, Gerhardt E, Enguita FJ, Fauvet B, Penque D, Pais TF, Tong Q, Becker S, Kügler S, Lashuel HA, Steegborn C, Zweckstetter M, Outeiro TF.
PLoS biology. 2017 Apr 5;15(4):e1002601. doi: 10.1371/journal.pbio.1002601. eCollection 2017 Apr.
PubMed

Sodium butyrate rescues dopaminergic cells from alpha-synuclein-induced transcriptional deregulation and DNA damage.
Paiva I, Pinho R, Pavlou MA, Hennion M, Wales P, Schütz AL, Rajput A, Szego ÉM, Kerimoglu C, Gerhardt E, Rego AC, Fischer A, Bonn S, Outeiro TF.
Human molecular genetics. 2017 Jun 15;26(12):2231-2246. doi: 10.1093/hmg/ddx114.
PubMed

Copper(II) and the pathological H50Q α-synuclein mutant: Environment meets genetics.
Villar-Piqué A, Rossetti G, Ventura S, Carloni P, Fernández CO, Outeiro TF.
Communicative & integrative biology. 2017 Feb 6;10(1):e1270484. doi: 10.1080/19420889.2016.1270484. eCollection 2017.
PubMed

The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.
de Oliveira RM, Vicente Miranda H, Francelle L, Pinho R, Szegö ÉM, Martinho R, Munari F, Lázaro DF, Moniot S, Guerreiro P, Fonseca-Ornelas L, Marijanovic Z, Antas P, Gerhardt E, Enguita FJ, Fauvet B, Penque D, Pais TF, Tong Q, Becker S, Kügler S, Lashuel HA, Steegborn C, Zweckstetter M, Outeiro TF.
PLoS biology. 2017 Mar 3;15(3):e2000374. doi: 10.1371/journal.pbio.2000374. eCollection 2017 Mar.
PubMed

A moderate metal-binding hydrazone meets the criteria for a bioinorganic approach towards Parkinson’s disease: Therapeutic potential, blood-brain barrier crossing evaluation and preliminary toxicological studies.
Cukierman DS, Pinheiro AB, Castiñeiras-Filho SL, da Silva AS, Miotto MC, De Falco A, de P Ribeiro T, Maisonette S, da Cunha AL, Hauser-Davis RA, Landeira-Fernandez J, Aucélio RQ, Outeiro TF, Pereira MD, Fernández CO, Rey NA.
Journal of inorganic biochemistry. 2017 May;170:160-168. doi: 10.1016/j.jinorgbio.2017.02.020. Epub 2017 Feb 22.
PubMed

Yeast models of Parkinson’s disease-associated molecular pathologies.
Tenreiro S, Franssens V, Winderickx J, Outeiro TF.
Current opinion in genetics & development. 2017 Jun;44:74-83. doi: 10.1016/j.gde.2017.01.013. Review.
PubMed

Alpha-synuclein prevents the formation of spherical mitochondria and apoptosis under oxidative stress.
Menges S, Minakaki G, Schaefer PM, Meixner H, Prots I, Schlötzer-Schrehardt U, Friedland K, Winner B, Outeiro TF, Winklhofer KF, von Arnim CA, Xiang W, Winkler J, Klucken J.
Scientific reports. 2017 Feb 22;7:42942. doi: 10.1038/srep42942.
PubMed

Contribution of Neuroepigenetics to Huntington’s Disease.
Francelle L, Lotz C, Outeiro T, Brouillet E, Merienne K.
Front Hum Neurosci. 2017 Jan 30;11:17. doi: 10.3389/fnhum.2017.00017. eCollection 2017. Review.
PubMed

Identification of a conserved gene signature associated with an exacerbated inflammatory environment in the hippocampus of aging rats.
Pardo J, Abba MC, Lacunza E, Francelle L, Morel GR, Outeiro TF, Goya RG.
Hippocampus. 2017 Apr;27(4):435-449. doi: 10.1002/hipo.22703. Epub 2017 Jan 23.
PubMed

The effects of the novel A53E alpha-synuclein mutation on its oligomerization and aggregation.
Lázaro DF, Dias MC, Carija A, Navarro S, Madaleno CS, Tenreiro S, Ventura S, Outeiro TF.
Acta Neuropathol Commun. 2016 Dec 9;4(1):128.
PubMed

A Novel Microfluidic Cell Co-culture Platform for the Study of the Molecular Mechanisms of Parkinson’s Disease and Other Synucleinopathies.
Fernandes JT, Chutna O, Chu V, Conde JP, Outeiro TF.
Front Neurosci. 2016 Nov 15;10:511. eCollection 2016.
PubMed

Glycation potentiates neurodegeneration in models of Huntington’s disease.
Vicente Miranda H, Gomes MA, Branco-Santos J, Breda C, Lázaro DF, Lopes LV, Herrera F, Giorgini F, Outeiro TF.
Sci Rep. 2016 Nov 18;6:36798. doi: 10.1038/srep36798.
PubMed

Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity.
Villar-Piqué A, Lopes da Fonseca T, Sant’Anna R, Szegö ÉM, Fonseca-Ornelas L, Pinho R, Carija A, Gerhardt E, Masaracchia C, Abad Gonzalez E, Rossetti G, Carloni P, Fernández CO, Foguel D, Milosevic I, Zweckstetter M, Ventura S, Outeiro TF.
Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6506-E6515. Epub 2016 Oct 5.
PubMed

Analysis of Protein Oligomeric Species by Sucrose Gradients.
Tenreiro S, Macedo D, Marijanovic Z, Outeiro TF.
Methods Mol Biol. 2016;1449:331-9. doi: 10.1007/978-1-4939-3756-1_21.
PubMed

The yin and yang of α-synuclein-associated epigenetics in Parkinson’s disease.
Pavlou MAS, Pinho R, Paiva I, Outeiro TF.
Brain. 2017 Apr 1;140(4):878-886. doi: 10.1093/brain/aww227.
PubMed

Mutant A53T α-Synuclein Improves Rotarod Performance Before Motor Deficits and Affects Metabolic Pathways.
Guerreiro PS, Coelho JE, Sousa-Lima I, Macedo P, Lopes LV, Outeiro TF, Pais TF.
Neuromolecular Med. 2017 Mar;19(1):113-121. doi: 10.1007/s12017-016-8435-5. Epub 2016 Aug 17.
PubMed

The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function.
Batalha VL, Ferreira DG, Coelho JE, Valadas JS, Gomes R, Temido-Ferreira M, Shmidt T, Baqi Y, Buée L, Müller CE, Hamdane M, Outeiro TF, Bader M, Meijsing SH, Sadri-Vakili G, Blum D, Lopes LV.
Sci Rep. 2016 Aug 11;6:31493. doi: 10.1038/srep31493.
PubMed

Distinct roles of N-acetyl and 5-methoxy groups in the antiproliferative and neuroprotective effects of melatonin.
Letra-Vilela R, Sánchez-Sánchez AM, Rocha AM, Martin V, Branco-Santos J, Puente-Moncada N, Santa-Marta M, Outeiro TF, Antolín I, Rodriguez C, Herrera F.
Mol Cell Endocrinol. 2016 Oct 15;434:238-49. doi: 10.1016/j.mce.2016.07.012. Epub 2016 Jul 9.
PubMed

C-Terminal Tyrosine Residue Modifications Modulate the Protective Phosphorylation of Serine 129 of α-Synuclein in a Yeast Model of Parkinson’s Disease.
Kleinknecht A, Popova B, Lázaro DF, Pinho R, Valerius O, Outeiro TF, Braus GH.
PLoS Genet. 2016 Jun 24;12(6):e1006098. doi: 10.1371/journal.pgen.1006098. eCollection 2016 Jun.
PubMed

Traffic jams and the complex role of α-Synuclein aggregation in Parkinson disease.
Gonçalves SA, Outeiro TF.
Small GTPases. 2017 Apr 3;8(2):78-84. doi: 10.1080/21541248.2016.1199191. Epub 2016 Jun 17. Review.
PubMed

A familial ATP13A2 mutation enhances alpha-synuclein aggregation and promotes cell death.
Lopes da Fonseca T, Pinho R, Outeiro TF.
Hum Mol Genet. 2016 Jul 15;25(14):2959-2971. Epub 2016 Jun 8.
PubMed

Insulin-like growth factor-I gene therapy increases hippocampal neurogenesis, astrocyte branching and improves spatial memory in female aging rats.
Pardo J, Uriarte M, Cónsole GM, Reggiani PC, Outeiro TF, Morel GR, Goya RG.
Eur J Neurosci. 2016 Aug;44(4):2120-8. doi: 10.1111/ejn.13278. Epub 2016 Jun 8.
PubMed

shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity.
Gonçalves SA, Macedo D, Raquel H, Simões PD, Giorgini F, Ramalho JS, Barral DC, Ferreira Moita L, Outeiro TF.
PLoS Genet. 2016 Apr 28;12(4):e1005995. doi: 10.1371/journal.pgen.1005995. eCollection 2016 Apr.
PubMed

Fasudil attenuates aggregation of α-synuclein in models of Parkinson’s disease.
Tatenhorst L, Eckermann K, Dambeck V, Fonseca-Ornelas L, Walle H, Lopes da Fonseca T, Koch JC, Becker S, Tönges L, Bähr M, Outeiro TF, Zweckstetter M, Lingor P.
Acta Neuropathol Commun. 2016 Apr 22;4:39. doi: 10.1186/s40478-016-0310-y.
PubMed

Cellular Uptake of α-Synuclein Oligomer-Selective Antibodies is Enhanced by the Extracellular Presence of α-Synuclein and Mediated via Fcγ Receptors.
Gustafsson G, Eriksson F, Möller C, da Fonseca TL, Outeiro TF, Lannfelt L, Bergström J, Ingelsson M.
Cell Mol Neurobiol. 2017 Jan;37(1):121-131. doi: 10.1007/s10571-016-0352-5. Epub 2016 Mar 10.
PubMed 

Glycation in Parkinson’s disease and Alzheimer’s disease.
Vicente Miranda H, El-Agnaf OM, Outeiro TF.
Mov Disord. 2016 Jun;31(6):782-90. doi: 10.1002/mds.26566. Epub 2016 Mar 4. Review.
PubMed

αB-Crystallin overexpression in astrocytes modulates the phenotype of the BACHD mouse model of Huntington’s disease.
Oliveira AO, Osmand A, Outeiro TF, Muchowski PJ, Finkbeiner S.
Hum Mol Genet. 2016 May 1;25(9):1677-89. doi: 10.1093/hmg/ddw028. Epub 2016 Feb 26.
PubMed

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky DJ, et al
Autophagy. 2016;12(1):1-222. doi: 10.1080/15548627.2015.1100356.
PubMed

Elevated α-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson’s patient-derived induced pluripotent stem cells.
Oliveira LM, Falomir-Lockhart LJ, Botelho MG, Lin KH, Wales P, Koch JC, Gerhardt E, Taschenberger H, Outeiro TF, Lingor P, Schüle B, Arndt-Jovin DJ, Jovin TM.
Cell death & disease. 2015 Nov 26;6:e1994. doi: 10.1038/cddis.2015.318.
PubMed

Yeast reveals similar molecular mechanisms underlying alpha- and beta-synuclein toxicity.
Tenreiro S, Rosado-Ramos R, Gerhardt E, Favretto F, Magalhães F, Popova B, Becker S, Zweckstetter M, Braus GH, Outeiro TF.
Human molecular genetics. 2016 Jan 15;25(2):275-90. doi: 10.1093/hmg/ddv470. Epub 2015 Nov 18.
PubMed

Emerging Role of Sirtuin 2 in the Regulation of Mammalian Metabolism.
Gomes P, Outeiro TF, Cavadas C.
Trends in pharmacological sciences. 2015 Nov;36(11):756-68. doi: 10.1016/j.tips.2015.08.001. Epub 2015 Nov 1. Review.
PubMed

Super-resolution Microscopy of Clickable Amino Acids Reveals the Effects of Fluorescent Protein Tagging on Protein Assemblies.
Vreja IC, Nikić I, Göttfert F, Bates M, Kröhnert K, Outeiro TF, Hell SW, Lemke EA, Rizzoli SO.
ACS nano”. 2015 Nov 24;9(11):11034-41. doi: 10.1021/acsnano.5b04434. Epub 2015 Oct 28.
PubMed

Small Molecules Detected by Second-Harmonic Generation Modulate the Conformation of Monomeric α-Synuclein and Reduce Its Aggregation in Cells.
Moree B, Yin G, Lázaro DF, Munari F, Strohäker T, Giller K, Becker S, Outeiro TF, Zweckstetter M, Salafsky J.
The Journal of biological chemistry. 2015 Nov 13;290(46):27582-93. doi: 10.1074/jbc.M114.636027. Epub 2015 Sep 22.
PubMed

Alpha-Synuclein Regulates Neuronal Levels of Manganese and Calcium.
Dučić T, Carboni E, Lai B, Chen S, Michalke B, Lázaro DF, Outeiro TF, Bähr M, Barski E, Lingor P.
ACS chemical neuroscience. 2015 Oct 21;6(10):1769-79. doi: 10.1021/acschemneuro.5b00093. Epub 2015 Aug 25.
PubMed

From the baker to the bedside: yeast models of Parkinson’s disease.
Menezes R, Tenreiro S, Macedo D, Santos CN, Outeiro TF.
Microbial cell (Graz, Austria). 2015 Jul 27;2(8):262-279. doi: 10.15698/mic2015.08.219. Review.
PubMed

Structure, function and toxicity of alpha-synuclein: the Bermuda triangle in synucleinopathies.
Villar-Piqué A, Lopes da Fonseca T, Outeiro TF.
Journal of neurochemistry. 2016 Oct;139 Suppl 1:240-255. doi: 10.1111/jnc.13249. Epub 2015 Sep 11. Review.
PubMed

LRRK2 Promotes Tau Accumulation, Aggregation and Release.
Guerreiro PS, Gerhardt E, Lopes da Fonseca T, Bähr M, Outeiro TF, Eckermann K.
Molecular neurobiology. 2016 Jul;53(5):3124-3135. doi: 10.1007/s12035-015-9209-z. Epub 2015 May 27.
PubMed

The Interplay between Alpha-Synuclein Clearance and Spreading.
Lopes da Fonseca T, Villar-Piqué A, Outeiro TF.
Biomolecules. 2015 Apr 14;5(2):435-71. doi: 10.3390/biom5020435. Review.
PubMed

Isostructural Re(I)/(99m)Tc(I) tricarbonyl complexes for cancer theranostics.
Nunes P, Morais GR, Palma E, Silva F, Oliveira MC, Ferreira VF, Mendes F, Gano L, Vicente Miranda H, Outeiro TF, Santos I, Paulo A.
Organic & biomolecular chemistry. 2015 May 14;13(18):5182-94. doi: 10.1039/c5ob00124b.
PubMed

Parkinson disease mutant E46K enhances α-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo.
Mbefo MK, Fares MB, Paleologou K, Oueslati A, Yin G, Tenreiro S, Pinto M, Outeiro T, Zweckstetter M, Masliah E, Lashuel HA.
J Biol Chem. 2015 Apr 10;290(15):9412-27. doi: 10.1074/jbc.M114.610774. Epub 2015 Feb 5.
PubMed

The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson’s disease but not amyotrophic lateral sclerosis and cerebral ischemia.
Chen X, Wales P, Quinti L, Zuo F, Moniot S, Herisson F, Rauf NA, Wang H, Silverman RB, Ayata C, Maxwell MM, Steegborn C, Schwarzschild MA, Outeiro TF, Kazantsev AG.
PloS one. 2015 Jan 21;10(1):e0116919. doi: 10.1371/journal.pone.0116919. eCollection 2015.
PubMed

ATP13A2 and Alpha-synuclein: a Metal Taste in Autophagy.
Lopes da Fonseca T, Outeiro TF.
Experimental neurobiology. 2014 Dec;23(4):314-23. doi: 10.5607/en.2014.23.4.314. Epub 2014 Dec 12. Review.
PubMed

Small molecule-mediated stabilization of vesicle-associated helical α-synuclein inhibits pathogenic misfolding and aggregation.
Fonseca-Ornelas L, Eisbach SE, Paulat M, Giller K, Fernández CO, Outeiro TF, Becker S, Zweckstetter M.
Nature communications. 2014 Dec 19;5:5857. doi: 10.1038/ncomms6857.
PubMed

Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment.
Poehler AM, Xiang W, Spitzer P, May VE, Meixner H, Rockenstein E, Chutna O, Outeiro TF, Winkler J, Masliah E, Klucken J.
Autophagy. 2014;10(12):2171-92. doi: 10.4161/auto.36436.
PubMed

α-Synuclein modifies mutant huntingtin aggregation and neurotoxicity in Drosophila.
Poças GM, Branco-Santos J, Herrera F, Outeiro TF, Domingos PM.
Human molecular genetics. 2015 Apr 1;24(7):1898-907. doi: 10.1093/hmg/ddu606. Epub 2014 Dec 1.
PubMed

(Poly)phenols protect from α-synuclein toxicity by reducing oxidative stress and promoting autophagy.
Macedo D, Tavares L, McDougall GJ, Vicente Miranda H, Stewart D, Ferreira RB, Tenreiro S, Outeiro TF, Santos CN.
Human molecular genetics. 2015 Mar 15;24(6):1717-32. doi: 10.1093/hmg/ddu585. Epub 2014 Nov 28.
PubMed

Systematic comparison of the effects of alpha-synuclein mutations on its oligomerization and aggregation.
Lázaro DF, Rodrigues EF, Langohr R, Shahpasandzadeh H, Ribeiro T, Guerreiro P, Gerhardt E, Kröhnert K, Klucken J, Pereira MD, Popova B, Kruse N, Mollenhauer B, Rizzoli SO, Braus GH, Danzer KM, Outeiro TF.
PLoS genetics. 2014 Nov 13;10(11):e1004741. doi: 10.1371/journal.pgen.1004741. eCollection 2014 Nov.
PubMed

Rab11 modulates α-synuclein-mediated defects in synaptic transmission and behaviour.
Breda C, Nugent ML, Estranero JG, Kyriacou CP, Outeiro TF, Steinert JR, Giorgini F.
Human molecular genetics. 2015 Feb 15;24(4):1077-91. doi: 10.1093/hmg/ddu521. Epub 2014 Oct 9.
PubMed

Interplay between sumoylation and phosphorylation for protection against α-synuclein inclusions.
Shahpasandzadeh H, Popova B, Kleinknecht A, Fraser PE, Outeiro TF, Braus GH.
The Journal of biological chemistry. 2014 Nov 7;289(45):31224-40. doi: 10.1074/jbc.M114.559237. Epub 2014 Sep 17.
PubMed

Modulation of alpha-synuclein toxicity in yeast using a novel microfluidic-based gradient generator.
Fernandes JT, Tenreiro S, Gameiro A, Chu V, Outeiro TF, Conde JP.
Lab on a chip. 2014 Oct 21;14(20):3949-57. doi: 10.1039/c4lc00756e.
PubMed

Mutant huntingtin alters Tau phosphorylation and subcellular distribution.
Blum D, Herrera F, Francelle L, Mendes T, Basquin M, Obriot H, Demeyer D, Sergeant N, Gerhardt E, Brouillet E, Buée L, Outeiro TF.
Human molecular genetics. 2015 Jan 1;24(1):76-85. doi: 10.1093/hmg/ddu421. Epub 2014 Aug 20.
PubMed

Linking alpha-synuclein phosphorylation to reactive oxygen species formation and mitochondrial dysfunction in SH-SY5Y cells.
Perfeito R, Lázaro DF, Outeiro TF, Rego AC.
Molecular and cellular neurosciences. 2014 Sep;62:51-9. doi: 10.1016/j.mcn.2014.08.002. Epub 2014 Aug 7.
PubMed

The small GTPase Rab11 co-localizes with α-synuclein in intracellular inclusions and modulates its aggregation, secretion and toxicity.
Chutna O, Gonçalves S, Villar-Piqué A, Guerreiro P, Marijanovic Z, Mendes T, Ramalho J, Emmanouilidou E, Ventura S, Klucken J, Barral DC, Giorgini F, Vekrellis K, Outeiro TF.
Human molecular genetics. 2014 Dec 20;23(25):6732-45. doi: 10.1093/hmg/ddu391. Epub 2014 Aug 4.
PubMed

DJ-1 interactions with α-synuclein attenuate aggregation and cellular toxicity in models of Parkinson’s disease.
Zondler L, Miller-Fleming L, Repici M, Gonçalves S, Tenreiro S, Rosado-Ramos R, Betzer C, Straatman KR, Jensen PH, Giorgini F, Outeiro TF.
Cell death & disease. 2014 Jul 24;5:e1350. doi: 10.1038/cddis.2014.307.
PubMed

α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner.
Yin G, Lopes da Fonseca T, Eisbach SE, Anduaga AM, Breda C, Orcellet ML, Szegő ÉM, Guerreiro P, Lázaro DF, Braus GH, Fernandez CO, Griesinger C, Becker S, Goody RS, Itzen A, Giorgini F, Outeiro TF, Zweckstetter M.
Neurobiology of disease. 2014 Oct;70:149-61. doi: 10.1016/j.nbd.2014.06.018. Epub 2014 Jun 28.
PubMed

Protein phosphorylation in neurodegeneration: friend or foe?
Tenreiro S, Eckermann K, Outeiro TF.
Frontiers in molecular neuroscience. 2014 May 13;7:42. doi: 10.3389/fnmol.2014.00042. eCollection 2014. Review.
PubMed

Phosphorylation modulates clearance of alpha-synuclein inclusions in a yeast model of Parkinson’s disease.
Tenreiro S, Reimão-Pinto MM, Antas P, Rino J, Wawrzycka D, Macedo D, Rosado-Ramos R, Amen T, Waiss M, Magalhães F, Gomes A, Santos CN, Kaganovich D, Outeiro TF.
PLoS genetics. 2014 May 8;10(5):e1004302. doi: 10.1371/journal.pgen.1004302. eCollection 2014 May.
PubMed

Yeast DJ-1 superfamily members are required for diauxic-shift reprogramming and cell survival in stationary phase.
Miller-Fleming L, Antas P, Pais TF, Smalley JL, Giorgini F, Outeiro TF.
Proceedings of the National Academy of Sciences of the United States of America. 2014 May 13;111(19):7012-7. doi: 10.1073/pnas.1319221111. Epub 2014 Apr 2. PubMed

Challenges and promises in the development of neurotrophic factor-based therapies for Parkinson’s disease.
Rodrigues TM, Jerónimo-Santos A, Outeiro TF, Sebastião AM, Diógenes MJ.
Drugs & aging. 2014 Apr;31(4):239-61. doi: 10.1007/s40266-014-0160-x. Review.
PubMed

Copy-number variation of the neuronal glucose transporter gene SLC2A3 and age of onset in Huntington’s disease.
Vittori A, Breda C, Repici M, Orth M, Roos RA, Outeiro TF, Giorgini F, Hollox EJ; REGISTRY investigators of the European Huntington’s Disease Network.
Human molecular genetics. 2014 Jun 15;23(12):3129-37. doi: 10.1093/hmg/ddu022. Epub 2014 Jan 22.
PubMed

β-Defensin Genomic Copy Number Does Not Influence the Age of Onset in Huntington’s Disease.
Vittori A, Orth M, Roos RA, Outeiro TF, Giorgini F, Hollox EJ; REGISTRY investigators of the European Huntington’s Disease Network.
Journal of Huntington’s disease”>J Huntingtons Dis. 2013 Mar 27;2(1):107-124.
PubMed

Limelight on alpha-synuclein: pathological and mechanistic implications in neurodegeneration.
Wales P, Pinho R, Lázaro DF, Outeiro TF.
Journal of Parkinson’s disease. 2013;3(4):415-59. doi: 10.3233/JPD-130216. Review.
PubMed

MeCP2: a novel Huntingtin interactor.
McFarland KN, Huizenga MN, Darnell SB, Sangrey GR, Berezovska O, Cha JH, Outeiro TF, Sadri-Vakili G.
Human molecular genetics. 2014 Feb 15;23(4):1036-44. doi: 10.1093/hmg/ddt499. Epub 2013 Oct 8.
PubMed

DJ-1 modulates aggregation and pathogenesis in models of Huntington’s disease.
Sajjad MU, Green EW, Miller-Fleming L, Hands S, Herrera F, Campesan S, Khoshnan A, Outeiro TF, Giorgini F, Wyttenbach A.
Human molecular genetics. 2014 Feb 1;23(3):755-66. doi: 10.1093/hmg/ddt466. Epub 2013 Sep 26.
PubMed

Off-pathway α-synuclein oligomers seem to alter α-synuclein turnover in a cell model but lack seeding capability in vivo.
Fagerqvist T, Näsström T, Ihse E, Lindström V, Sahlin C, Tucker SM, Kasaryan A, Karlsson M, Nikolajeff F, Schell H, Outeiro TF, Kahle PJ, Lannfelt L, Ingelsson M, Bergström J.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. 2013 Dec;20(4):233-44. doi: 10.3109/13506129.2013.835726. Epub 2013 Sep 20.
PubMed

The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation.
Pais TF, Szegő ÉM, Marques O, Miller-Fleming L, Antas P, Guerreiro P, de Oliveira RM, Kasapoglu B, Outeiro TF.
The EMBO journal. 2013 Oct 2;32(19):2603-16. doi: 10.1038/emboj.2013.200. Epub 2013 Sep 6.
PubMed

PLK2 modulates α-synuclein aggregation in yeast and mammalian cells.
Basso E, Antas P, Marijanovic Z, Gonçalves S, Tenreiro S, Outeiro TF.
Molecular neurobiology. 2013 Dec;48(3):854-62. doi: 10.1007/s12035-013-8473-z. Epub 2013 May 17.
PubMed

The causative role and therapeutic potential of the kynurenine pathway in neurodegenerative disease.
Amaral M, Outeiro TF, Scrutton NS, Giorgini F.
Journal of molecular medicine (Berlin, Germany). 2013 Jun;91(6):705-13. doi: 10.1007/s00109-013-1046-9. Epub 2013 May 1. Review.
PubMed

Alpha-synuclein and intracellular trafficking: impact on the spreading of Parkinson’s disease pathology.
Eisbach SE, Outeiro TF.
Journal of molecular medicine (Berlin, Germany). 2013 Jun;91(6):693-703. doi: 10.1007/s00109-013-1038-9. Epub 2013 Apr 25. Review.
PubMed

Inhibition of formation of α-synuclein inclusions by mannosylglycerate in a yeast model of Parkinson’s disease.
Faria C, Jorge CD, Borges N, Tenreiro S, Outeiro TF, Santos H.
Biochimica et biophysica acta. 2013 Aug;1830(8):4065-72. doi: 10.1016/j.bbagen.2013.04.015. Epub 2013 Apr 19.
PubMed

Harnessing the power of yeast to unravel the molecular basis of neurodegeneration.
Tenreiro S, Munder MC, Alberti S, Outeiro TF.
Journal of neurochemistry. 2013 Nov;127(4):438-52. doi: 10.1111/jnc.12271. Epub 2013 May 8. Review.
PubMed

Structural basis of kynurenine 3-monooxygenase inhibition.
Amaral M, Levy C, Heyes DJ, Lafite P, Outeiro TF, Giorgini F, Leys D, Scrutton NS.
Nature. 2013 Apr 18;496(7445):382-5. doi: 10.1038/nature12039. Epub 2013 Apr 10.
PubMed

β-synuclein aggregates and induces neurodegeneration in dopaminergic neurons.
Taschenberger G, Toloe J, Tereshchenko J, Akerboom J, Wales P, Benz R, Becker S, Outeiro TF, Looger LL, Bähr M, Zweckstetter M, Kügler S.
Annals of neurology. 2013 Jul;74(1):109-18. doi: 10.1002/ana.23905. Epub 2013 Aug 6.
PubMed

Heat-mediated enrichment of α-synuclein from cells and tissue for assessing post-translational modifications.
Vicente Miranda H, Xiang W, de Oliveira RM, Simões T, Pimentel J, Klucken J, Penque D, Outeiro TF.
Journal of neurochemistry. 2013 Sep;126(5):673-84. doi: 10.1111/jnc.12251. Epub 2013 Apr 25.
PubMed

Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies.
Schildknecht S, Gerding HR, Karreman C, Drescher M, Lashuel HA, Outeiro TF, Di Monte DA, Leist M.
Journal of neurochemistry. 2013 May;125(4):491-511. doi: 10.1111/jnc.12226. Epub 2013 Mar 19. Review.
PubMed

SIRT1 and SIRT2: emerging targets in neurodegeneration.
Donmez G, Outeiro TF.
EMBO molecular medicine. 2013 Mar;5(3):344-52. doi: 10.1002/emmm.201302451. Epub 2013 Feb 18. Review.
PubMed

Assessing the subcellular dynamics of alpha-synuclein using photoactivation microscopy.
Gonçalves S, Outeiro TF.
Molecular neurobiology. 2013 Jun;47(3):1081-92. doi: 10.1007/s12035-013-8406-x. Epub 2013 Feb 8.
PubMed

β-Defensin genomic copy number does not influence the age of onset in Huntington’s Disease.
Vittori A, Orth M, Roos RA, Outeiro TF, Giorgini F, Hollox EJ; Registry investigators of the European Huntington’s Disease Network.
Journal of Huntington’s disease. 2013;2(1):107-24. doi: 10.3233/JHD-130002.
PubMed

Live-cell imaging of p53 interactions using a novel Venus-based bimolecular fluorescence complementation system.
Amaral JD, Herrera F, Rodrigues PM, Dionísio PA, Outeiro TF, Rodrigues CM.
Biochemical pharmacology. 2013 Mar 15;85(6):745-52. doi: 10.1016/j.bcp.2012.12.009. Epub 2012 Dec 19.
PubMed

LRRK2 interactions with α-synuclein in Parkinson’s disease brains and in cell models.
Guerreiro PS, Huang Y, Gysbers A, Cheng D, Gai WP, Outeiro TF, Halliday GM.
Journal of molecular medicine (Berlin, Germany). 2013 Apr;91(4):513-22. doi: 10.1007/s00109-012-0984-y. Epub 2012 Nov 27.
PubMed

Parkinson’s disease-associated mutations in DJ-1 modulate its dimerization in living cells.
Repici M, Straatman KR, Balduccio N, Enguita FJ, Outeiro TF, Giorgini F.
Journal of molecular medicine (Berlin, Germany). 2013 May;91(5):599-611. doi: 10.1007/s00109-012-0976-y. Epub 2012 Nov 27.
PubMed

Epigenetics in Parkinson’s and Alzheimer’s diseases.
Marques S, Outeiro TF.
Sub-cellular biochemistry. 2013;61:507-25. doi: 10.1007/978-94-007-4525-4_22. Review.
PubMed

The zebrafish homologue of Parkinson’s disease ATP13A2 is essential for embryonic survival.
Lopes da Fonseca T, Correia A, Hasselaar W, van der Linde HC, Willemsen R, Outeiro TF.
Brain research bulletin. 2013 Jan;90:118-26. doi: 10.1016/j.brainresbull.2012.09.017. Epub 2012 Oct 31.
PubMed

Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation.
Diógenes MJ, Dias RB, Rombo DM, Vicente Miranda H, Maiolino F, Guerreiro P, Näsström T, Franquelim HG, Oliveira LM, Castanho MA, Lannfelt L, Bergström J, Ingelsson M, Quintas A, Sebastião AM, Lopes LV, Outeiro TF.
J Neurosci. 2012 Aug 22;32(34):11750-62.
PubMed

SNCA (α-synuclein)-induced toxicity in yeast cells is dependent on sirtuin 2 (Sir2)-mediated mitophagy.
Sampaio-Marques B, Felgueiras C, Silva A, Rodrigues M, Tenreiro S, Franssens V, Reichert AS, Outeiro TF, Winderickx J, Ludovico P.
Autophagy. 2012 Oct;8(10):1494-509. doi: 10.4161/auto.21275. Epub 2012 Aug 23.
PubMed

Alpha-synuclein: from secretion to dysfunction and death.
Marques O, Outeiro TF.
Cell Death Dis. 2012 Jul 19;3:e350. doi: 10.1038/cddis.2012.94. Review.
PubMed

Epigenetic regulation of BACE1 in Alzheimer’s disease patients and in transgenic mice.
Marques SC, Lemos R, Ferreiro E, Martins M, de Mendonça A, Santana I, Outeiro TF, Pereira CM.
Neuroscience. 2012 Sep 18;220:256-66. doi: 10.1016/j.neuroscience.2012.06.029. Epub 2012 Jun 21.
PubMed

Aggregate clearance of α-synuclein in Saccharomyces cerevisiae depends more on autophagosome and vacuole function than on the proteasome.
Petroi D, Popova B, Taheri-Talesh N, Irniger S, Shahpasandzadeh H, Zweckstetter M, Outeiro TF, Braus GH.
J Biol Chem. 2012 Aug 10;287(33):27567-79. doi: 10.1074/jbc.M112.361865. Epub 2012 Jun 21.
PubMed

High-throughput study of alpha-synuclein expression in yeast using microfluidics for control of local cellular microenvironment.
Rosa P, Tenreiro S, Chu V, Outeiro TF, Conde JP.
Biomicrofluidics. 2012 Mar;6(1):14109-141099. doi: 10.1063/1.3683161. Epub 2012 Feb 9.
PubMed

Highlights of the Keystone Symposium: sirtuins in metabolism, aging and disease.
Maxwell MM, Zaldivar-Jolissaint JF, Mai A, Outeiro TF, Kazanstev AG.
EMBO Mol Med. 2012 Jul;4(7):557-60. doi: 10.1002/emmm.201201452. Epub 2012 May 18.
PubMed

Impairment of the septal cholinergic neurons in MPTP-treated A30P α-synuclein mice.
Szegő ÉM, Outeiro TF, Kermer P, Schulz JB.
Neurobiol Aging. 2013 Feb;34(2):589-601. doi: 10.1016/j.neurobiolaging.2012.04.012. Epub 2012 May 11.
PubMed

SIRT2 as a Therapeutic Target for Age-Related Disorders.
de Oliveira RM, Sarkander J, Kazantsev AG, Outeiro TF.
Front Pharmacol. 2012 May 3;3:82. doi: 10.3389/fphar.2012.00082. eCollection 2012.
PubMed

Editorial on special topic: sirtuins in metabolism, aging, and disease.
Kazantsev AG, Outeiro TF.
Front Pharmacol. 2012 Apr 24;3:71. doi: 10.3389/fphar.2012.00071. eCollection 2012. No abstract available.
PubMed

Suppression of α-synuclein toxicity and vesicle trafficking defects by phosphorylation at S129 in yeast depends on genetic context.
Sancenon V, Lee SA, Patrick C, Griffith J, Paulino A, Outeiro TF, Reggiori F, Masliah E, Muchowski PJ.
Hum Mol Genet. 2012 Jun 1;21(11):2432-49. doi: 10.1093/hmg/dds058. Epub 2012 Feb 21.
PubMed

Imaging protein oligomerization in neurodegeneration using bimolecular fluorescence complementation.
Herrera F, Gonçalves S, Outeiro TF.
Methods Enzymol. 2012;506:157-74. doi: 10.1016/B978-0-12-391856-7.00033-0.
PubMed

Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice.
Kemppainen S, Rantamäki T, Jerónimo-Santos A, Lavasseur G, Autio H, Karpova N, Kärkkäinen E, Stavén S, Vicente Miranda H, Outeiro TF, Diógenes MJ, Laroche S, Davis S, Sebastião AM, Castrén E, Tanila H.
Neurobiol Aging. 2012 Jun;33(6):1122.e23-39. doi: 10.1016/j.neurobiolaging.2011.11.006. Epub 2011 Dec 30.
PubMed

Idebenone and resveratrol extend lifespan and improve motor function of HtrA2 knockout mice.
Gerhardt E, Gräber S, Szego EM, Moisoi N, Martins LM, Outeiro TF, Kermer P.
PLoS One. 2011;6(12):e28855. doi: 10.1371/journal.pone.0028855. Epub 2011 Dec 19.
PubMed

α-Synuclein modifies huntingtin aggregation in living cells.
Herrera F, Outeiro TF.
FEBS Lett. 2012 Jan 2;586(1):7-12. doi: 10.1016/j.febslet.2011.11.019. Epub 2011 Nov 24.
PubMed

Synthesis and in vitro evaluation of fluorinated styryl benzazoles as amyloid-probes.
Ribeiro Morais G, Vicente Miranda H, Santos IC, Santos I, Outeiro TF, Paulo A.
Bioorg Med Chem. 2011 Dec 15;19(24):7698-710. doi: 10.1016/j.bmc.2011.09.065. Epub 2011 Oct 18.
PubMed

Antibodies against alpha-synuclein reduce oligomerization in living cells.
Näsström T, Gonçalves S, Sahlin C, Nordström E, Screpanti Sundquist V, Lannfelt L, Bergström J, Outeiro TF, Ingelsson M.
PLoS One. 2011;6(10):e27230. doi: 10.1371/journal.pone.0027230. Epub 2011 Oct 31.
PubMed

Tau enhances α-synuclein aggregation and toxicity in cellular models of synucleinopathy.
Badiola N, de Oliveira RM, Herrera F, Guardia-Laguarta C, Gonçalves SA, Pera M, Suárez-Calvet M, Clarimon J, Outeiro TF, Lleó A.
PLoS One. 2011;6(10):e26609. doi: 10.1371/journal.pone.0026609. Epub 2011 Oct 24.
PubMed

Convergence of miRNA expression profiling, α-synuclein interacton and GWAS in Parkinson’s disease.
Martins M, Rosa A, Guedes LC, Fonseca BV, Gotovac K, Violante S, Mestre T, Coelho M, Rosa MM, Martin ER, Vance JM, Outeiro TF, Wang L, Borovecki F, Ferreira JJ, Oliveira SA.
PLoS One. 2011;6(10):e25443. doi: 10.1371/journal.pone.0025443. Epub 2011 Oct 7.
PubMed

Aggresome formation and segregation of inclusions influence toxicity of α-synuclein and synphilin-1 in yeast.
Swinnen E, Büttner S, Outeiro TF, Galas MC, Madeo F, Winderickx J, Franssens V.
Biochem Soc Trans. 2011 Oct;39(5):1476-81. doi: 10.1042/BST0391476. Review.
PubMed

Amyloidogenesis: FlAsH illuminates Aβ aggregation.
Outeiro TF.
Nat Chem Biol. 2011 Aug 17;7(9):581-2. doi: 10.1038/nchembio.636. No abstract available.
PubMed

Dopamine-depletion and increased α-synuclein load induce degeneration of cortical cholinergic fibers in mice.
Szego ÉM, Gerhardt E, Outeiro TF, Kermer P.
J Neurol Sci. 2011 Nov 15;310(1-2):90-5. doi: 10.1016/j.jns.2011.06.048. Epub 2011 Jul 19.
PubMed

Impaired proteostasis contributes to renal tubular dysgenesis.
de Oliveira RM, Marijanovic Z, Carvalho F, Miltényi GM, Matos JE, Tenreiro S, Oliveira S, Enguita FJ, Stone R, Outeiro TF.
PLoS One. 2011;6(6):e20854. doi: 10.1371/journal.pone.0020854. Epub 2011 Jun 9.
PubMed

Modulating Alzheimer’s disease through caffeine: a putative link to epigenetics.
Marques S, Batalha VL, Lopes LV, Outeiro TF.
J Alzheimers Dis. 2011;24 Suppl 2:161-71. doi: 10.3233/JAD-2011-110032. Review.
PubMed

Assessment of the efficacy of solutes from extremophiles on protein aggregation in cell models of Huntington’s and Parkinson’s diseases.
Jorge CD, Ventura R, Maycock C, Outeiro TF, Santos H, Costa J.
Neurochem Res. 2011 Jun;36(6):1005-11. doi: 10.1007/s11064-011-0440-3. Epub 2011 Mar 17.
PubMed

Visualization of cell-to-cell transmission of mutant huntingtin oligomers.
Herrera F, Tenreiro S, Miller-Fleming L, Outeiro TF.
PLoS Curr. 2011 Feb 11;3:RRN1210. doi: 10.1371/currents.RRN1210.
PubMed

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells.
Hansen C, Angot E, Bergström AL, Steiner JA, Pieri L, Paul G, Outeiro TF, Melki R, Kallunki P, Fog K, Li JY, Brundin P.
J Clin Invest. 2011 Feb;121(2):715-25. doi: 10.1172/JCI43366. Epub 2011 Jan 18.
PubMed

A non-invasive method based on saliva to characterize transthyretin in familial amyloidotic polyneuropathy patients using FT-ICR high-resolution MS.
da Costa G, Guerreiro A, Correia CF, Gomes RJ, Freire A, Monteiro E, Barroso E, Coelho AV, Outeiro TF, Freire AP, Cordeiro C.
Proteomics Clin Appl. 2010 Jul;4(6-7):674-8.
PubMed

Synphilin-1 enhances α-synuclein aggregation in yeast and contributes to cellular stress and cell death in a Sir2-dependent manner.
Büttner S, Delay C, Franssens V, Bammens T, Ruli D, Zaunschirm S, de Oliveira RM, Outeiro TF, Madeo F, Buée L, Galas MC, Winderickx
PLoS One. 2010 Oct 27;5(10):e13700. doi: 10.1371/journal.pone.0013700.
PubMed

Functional gene expression profiling in yeast implicates translational dysfunction in mutant huntingtin toxicity.
Tauber E, Miller-Fleming L, Mason RP, Kwan W, Clapp J, Butler NJ, Outeiro TF, Muchowski PJ, Giorgini F.
J Biol Chem. 2011 Jan 7;286(1):410-9. doi: 10.1074/jbc.M110.101527. Epub 2010 Nov 2.
PubMed

Neurotrophic factors as a protective strategy in Parkinson’s disease.
Diógenes MJ, Outeiro TF.
CNS Neurol Disord Drug Targets. 2010 Dec;9(6):754-63. Review.
PubMed

Drug discovery for CNS disorders: from bench to bedside.
Kazantsev AG, Outeiro TF.
CNS Neurol Disord Drug Targets. 2010 Dec;9(6):668. No abstract available.
PubMed

Sirtuins: common targets in aging and in neurodegeneration.
de Oliveira RM, Pais TF, Outeiro TF.
Curr Drug Targets. 2010 Oct;11(10):1270-80. Review.
PubMed

Epigenetics in neurodegeneration: a new layer of complexity.
Marques SC, Oliveira CR, Pereira CM, Outeiro TF.
Prog Neuropsychopharmacol Biol Psychiatry. 2011 Mar 30;35(2):348-55. doi: 10.1016/j.pnpbp.2010.08.008. Epub 2010 Aug 22. Review.
PubMed

Simple is good: yeast models of neurodegeneration.
Tenreiro S, Outeiro TF.
FEMS Yeast Res. 2010 Dec;10(8):970-9. doi: 10.1111/j.1567-1364.2010.00649.x. Review.
PubMed

Simple is good: yeast models of neurodegeneration.
Tenreiro S, Outeiro TF.
FEMS Yeast Res. 2010 Dec;10(8):970-9. doi: 10.1111/j.1567-1364.2010.00649.x. Review.
PubMed

Zooming into protein oligomerization in neurodegeneration using BiFC.
Gonçalves SA, Matos JE, Outeiro TF.
Trends Biochem Sci. 2010 Nov;35(11):643-51. doi: 10.1016/j.tibs.2010.05.007. Epub 2010 Jun 17. Review.
PubMed

Alzheimer’s disease: the quest to understand complexity.
Marques SC, Oliveira CR, Outeiro TF, Pereira CM.
J Alzheimers Dis. 2010;21(2):373-83. doi: 10.3233/JAD-2010-100303. Review.
PubMed

Increased serum HSP70 levels are associated with the duration of diabetes.
Nakhjavani M, Morteza A, Khajeali L, Esteghamati A, Khalilzadeh O, Asgarani F, Outeiro TF.
Cell Stress Chaperones. 2010 Nov;15(6):959-64. doi: 10.1007/s12192-010-0204-z. Epub 2010 May 23.
PubMed

The sour side of neurodegenerative disorders: the effects of protein glycation.
Vicente Miranda H, Outeiro TF.
J Pathol. 2010 May;221(1):13-25. doi: 10.1002/path.2682. Review.
PubMed

Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson’s disease models.
Su LJ, Auluck PK, Outeiro TF, Yeger-Lotem E, Kritzer JA, Tardiff DF, Strathearn KE, Liu F, Cao S, Hamamichi S, Hill KJ, Caldwell KA, Bell GW, Fraenkel E, Cooper AA, Caldwell GA, McCaffery JM, Rochet JC, Lindquist S.
Dis Model Mech. 2010 Mar-Apr;3(3-4):194-208. doi: 10.1242/dmm.004267. Epub 2009 Dec 28.
PubMed

Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson’s disease models.
Su LJ, Auluck PK, Outeiro TF, Yeger-Lotem E, Kritzer JA, Tardiff DF, Strathearn KE, Liu F, Cao S, Hamamichi S, Hill KJ, Caldwell KA, Bell GW, Fraenkel E, Cooper AA, Caldwell GA, McCaffery JM, Rochet JC, Lindquist S.
Dis Model Mech. 2010 Mar-Apr;3(3-4):194-208. doi: 10.1242/dmm.004267. Epub 2009 Dec 28.
PubMed

Identification and quantitative analysis of human transthyretin variants in human serum by Fourier transform ion-cyclotron resonance mass spectrometry.
da Costa G, Gomes R, Correia CF, Freire A, Monteiro E, Martins A, Barroso E, Coelho AV, Outeiro TF, Ponces Freire A, Cordeiro C.
Amyloid. 2009 Dec;16(4):201-7. doi: 10.3109/13506120903421561.
PubMe

Current and future therapeutic strategies for Parkinson’s disease.
Outeiro TF, Ferreira J.
Curr Pharm Des. 2009;15(34):3968-76.
PubMed

Dopamine-induced conformational changes in alpha-synuclein.
Outeiro TF, Klucken J, Bercury K, Tetzlaff J, Putcha P, Oliveira LM, Quintas A, McLean PJ, Hyman BT.
PLoS One. 2009 Sep 4;4(9):e6906. doi: 10.1371/journal.pone.0006906
PubMed

Direct quantification of CSF alpha-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration.
Mollenhauer B, Cullen V, Kahn I, Krastins B, Outeiro TF, Pepivani I, Ng J, Schulz-Schaeffer W, Kretzschmar HA, McLean PJ, Trenkwalder C, Sarracino DA, Vonsattel JP, Locascio JJ, El-Agnaf OM, Schlossmacher MG.
Exp Neurol. 2008 Oct;213(2):315-25. doi: 10.1016/j.expneurol.2008.06.004. Epub 2008 Jun 14.
PubMed

CHIP targets toxic alpha-Synuclein oligomers for degradation.
Tetzlaff JE, Putcha P, Outeiro TF, Ivanov A, Berezovska O, Hyman BT, McLean PJ.
J Biol Chem. 2008 Jun 27;283(26):17962-8. doi: 10.1074/jbc.M802283200. Epub 2008 Apr 24.
PubMed

Formation of toxic oligomeric alpha-synuclein species in living cells.
Outeiro TF, Putcha P, Tetzlaff JE, Spoelgen R, Koker M, Carvalho F, Hyman BT, McLean PJ.
PLoS One. 2008 Apr 2;3(4):e1867. doi: 10.1371/journal.pone.0001867. Erratum in: PLoS One. 2008;3(5). doi: 10.1371/annotation/9282f173-df82-4b70-9120-b4e62b3dacb1.
PubMed

Detection of compounds that rescue Rab1-synuclein toxicity.
Fleming J, Outeiro TF, Slack M, Lindquist SL, Bulawa CE.
Methods Enzymol. 2008;439:339-51. doi: 10.1016/S0076-6879(07)00425-9.
PubMed

Therapeutic role of sirtuins in neurodegenerative disease.
Outeiro TF, Marques O, Kazantsev A.
Biochim Biophys Acta. 2008 Jun;1782(6):363-9. doi: 10.1016/j.bbadis.2008.02.010. Epub 2008 Mar 7. Review.
PubMed

Yeast as a model for studying human neurodegenerative disorders.
Miller-Fleming L, Giorgini F, Outeiro TF.
Biotechnol J. 2008 Mar;3(3):325-38. doi: 10.1002/biot.200700217. Review. Erratum in: Biotechnol J. 2008 Mar;3(3):421.
PubMed

Drug Targeting of alpha-Synuclein Oligomerization in Synucleinopathies.
Outeiro TF, Kazantsev A.
Perspect Medicin Chem. 2008 Apr 10;2:41-9.
PubMed

Angiotensin II protects against alpha-synuclein toxicity and reduces protein aggregation in vitro.
Grammatopoulos TN, Outeiro TF, Hyman BT, Standaert DG.
Biochem Biophys Res Commun. 2007 Nov 23;363(3):846-51. Epub 2007 Sep 21.
PubMed

Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson’s disease.
Outeiro TF, Kontopoulos E, Altmann SM, Kufareva I, Strathearn KE, Amore AM, Volk CB, Maxwell MM, Rochet JC, McLean PJ, Young AB, Abagyan R, Feany MB, Hyman BT, Kazantsev AG.
Science. 2007 Jul 27;317(5837):516-9. Epub 2007 Jun 21.
PubMed

Pharmacological inhibition of PARP-1 reduces alpha-synuclein- and MPP+-induced cytotoxicity in Parkinson’s disease in vitro models.
Outeiro TF, Grammatopoulos TN, Altmann S, Amore A, Standaert DG, Hyman BT, Kazantsev AG.
Biochem Biophys Res Commun. 2007 Jun 8;357(3):596-602. Epub 2007 Apr 5.
PubMed

Mechanisms of disease II: cellular protein quality control.
Outeiro TF, Tetzlaff J.
Semin Pediatr Neurol. 2007 Mar;14(1):15-25. Review.
PubMed

Dopaminergic neuron loss and up-regulation of chaperone protein mRNA induced by targeted over-expression of alpha-synuclein in mouse substantia nigra.
St Martin JL, Klucken J, Outeiro TF, Nguyen P, Keller-McGandy C, Cantuti-Castelvetri I, Grammatopoulos TN, Standaert DG, Hyman BT, McLean PJ.
J Neurochem. 2007 Mar;100(6):1449-57. Epub 2007 Jan 4.
PubMed

Small heat shock proteins protect against alpha-synuclein-induced toxicity and aggregation.
Outeiro TF, Klucken J, Strathearn KE, Liu F, Nguyen P, Rochet JC, Hyman BT, McLean PJ.
Biochem Biophys Res Commun. 2006 Dec 22;351(3):631-8. Epub 2006 Oct 26.
PubMed

Detection of novel intracellular alpha-synuclein oligomeric species by fluorescence lifetime imaging.
Klucken J, Outeiro TF, Nguyen P, McLean PJ, Hyman BT.
FASEB J. 2006 Oct;20(12):2050-7.
PubMed

A bridge from Portugal to the States.
Outeiro TF.
Nature. 2006 Sep 7;443(7107):118. No abstract available.
PubMed

Yeast as a drug discovery platform in Huntington’s and Parkinson’s diseases.
Outeiro TF, Giorgini F.
Biotechnol J. 2006 Mar;1(3):258-69. Review.
PubMed

Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington’s and Parkinson’s diseases.
Bodner RA, Outeiro TF, Altmann S, Maxwell MM, Cho SH, Hyman BT, McLean PJ, Young AB, Housman DE, Kazantsev AG.
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4246-51. Epub 2006 Mar 6.
PubMed

Effects of Q/N-rich, polyQ, and non-polyQ amyloids on the de novo formation of the [PSI+] prion in yeast and aggregation of Sup35 in vitro.
Derkatch IL, Uptain SM, Outeiro TF, Krishnan R, Lindquist SL, Liebman SW.
Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):12934-9. Epub 2004 Aug 23.
PubMed

Molecular genetics approaches in yeast to study amyloid diseases.
Outeiro TF, Muchowski PJ.
J Mol Neurosci. 2004;23(1-2):49-60. Review.
PubMed

Interactions among alpha-synuclein, dopamine, and biomembranes: some clues for understanding neurodegeneration in Parkinson’s disease.
Rochet JC, Outeiro TF, Conway KA, Ding TT, Volles MJ, Lashuel HA, Bieganski RM, Lindquist SL, Lansbury PT.
J Mol Neurosci. 2004;23(1-2):23-34. Review.
PubMed

Yeast cells provide insight into alpha-synuclein biology and pathobiology.
Outeiro TF, Lindquist S.
Science. 2003 Dec 5;302(5651):1772-5.
PubMed

Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein.
Willingham S, Outeiro TF, DeVit MJ, Lindquist SL, Muchowski PJ.
Science. 2003 Dec 5;302(5651):1769-72.
PubMed

Prion protein gene polymorphisms in Saccharomyces cerevisiae.
Resende CG, Outeiro TF, Sands L, Lindquist S, Tuite MF.
Mol Microbiol. 2003 Aug;49(4):1005-17.
PubMed

Antibodies against alpha-synuclein reduce oligomerization in living cells.
Näsström T, Gonçalves S, Sahlin C, Nordström E, Screpanti Sundquist V, Lannfelt L, Bergström J, Outeiro TF, Ingelsson M.
PLoS One. 2011;6(10):e27230. doi: 10.1371/journal.pone.0027230. Epub 2011 Oct 31.
PubMed

Tau enhances α-synuclein aggregation and toxicity in cellular models of synucleinopathy.
Badiola N, de Oliveira RM, Herrera F, Guardia-Laguarta C, Gonçalves SA, Pera M, Suárez-Calvet M, Clarimon J, Outeiro TF, Lleó A.
PLoS One. 2011;6(10):e26609. doi: 10.1371/journal.pone.0026609. Epub 2011 Oct 24.
PubMed

Convergence of miRNA expression profiling, α-synuclein interacton and GWAS in Parkinson’s disease.
Martins M, Rosa A, Guedes LC, Fonseca BV, Gotovac K, Violante S, Mestre T, Coelho M, Rosa MM, Martin ER, Vance JM, Outeiro TF, Wang L, Borovecki F, Ferreira JJ, Oliveira SA.
PLoS One. 2011;6(10):e25443. doi: 10.1371/journal.pone.0025443. Epub 2011 Oct 7.
PubMed

Aggresome formation and segregation of inclusions influence toxicity of α-synuclein and synphilin-1 in yeast.
Swinnen E, Büttner S, Outeiro TF, Galas MC, Madeo F, Winderickx J, Franssens V.
Biochem Soc Trans. 2011 Oct;39(5):1476-81. doi: 10.1042/BST0391476. Review.
PubMed

Amyloidogenesis: FlAsH illuminates Aβ aggregation.
Outeiro TF.
Nat Chem Biol. 2011 Aug 17;7(9):581-2. doi: 10.1038/nchembio.636. No abstract available.
PubMed

Dopamine-depletion and increased α-synuclein load induce degeneration of cortical cholinergic fibers in mice.
Szego ÉM, Gerhardt E, Outeiro TF, Kermer P.
J Neurol Sci. 2011 Nov 15;310(1-2):90-5. doi: 10.1016/j.jns.2011.06.048. Epub 2011 Jul 19.
PubMed

Impaired proteostasis contributes to renal tubular dysgenesis.
de Oliveira RM, Marijanovic Z, Carvalho F, Miltényi GM, Matos JE, Tenreiro S, Oliveira S, Enguita FJ, Stone R, Outeiro TF.
PLoS One. 2011;6(6):e20854. doi: 10.1371/journal.pone.0020854. Epub 2011 Jun 9.
PubMed

Modulating Alzheimer’s disease through caffeine: a putative link to epigenetics.
Marques S, Batalha VL, Lopes LV, Outeiro TF.
J Alzheimers Dis. 2011;24 Suppl 2:161-71. doi: 10.3233/JAD-2011-110032. Review.
PubMed

Assessment of the efficacy of solutes from extremophiles on protein aggregation in cell models of Huntington’s and Parkinson’s diseases.
Jorge CD, Ventura R, Maycock C, Outeiro TF, Santos H, Costa J.
Neurochem Res. 2011 Jun;36(6):1005-11. doi: 10.1007/s11064-011-0440-3. Epub 2011 Mar 17.
PubMed

Visualization of cell-to-cell transmission of mutant huntingtin oligomers.
Herrera F, Tenreiro S, Miller-Fleming L, Outeiro TF.
PLoS Curr. 2011 Feb 11;3:RRN1210. doi: 10.1371/currents.RRN1210.
PubMed

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells.
Hansen C, Angot E, Bergström AL, Steiner JA, Pieri L, Paul G, Outeiro TF, Melki R, Kallunki P, Fog K, Li JY, Brundin P.
J Clin Invest. 2011 Feb;121(2):715-25. doi: 10.1172/JCI43366. Epub 2011 Jan 18.
PubMed